149697-30-3Relevant academic research and scientific papers
Novel cajaninstilbene acid derivatives as antibacterial agents
Geng, Zhi-Zhong,Zhang, Jian-Jun,Lin, Jing,Huang, Mei-Yan,An, Lin-Kun,Zhang, Hong-Bin,Sun, Ping-Hua,Ye, Wen-Cai,Chen, Wei-Min
, p. 235 - 245 (2015)
Discovery of novel antibacterial agents with new structural scaffolds that combat drug-resistant pathogens is an urgent task. Cajaninstilbene acid, which is isolated from pigeonpea leaves, has shown antibacterial activity. In this study, a series of cajaninstilbene acid derivatives were designed and synthesized. The antibacterial activities of these compounds against gram-negative and gram-positive bacteria, as well as nine strains of methicillin-resistant staphylococcus aureus (MRSA) bacteria are evaluated, and the related structure-activity relationships are discussed. Assays suggest that some of the synthetic cajaninstilbene acid derivatives exhibit potent antibacterial activity against gram-positive bacterial strains and MRSA. Among these compounds, 5b, 5c, 5j and 5k show better antibacterial activity than the positive control compounds. The results of MTT assays illustrate the low cytotoxicity of the active compounds.
Cajan element structure and methods in the application of preparing antibacterial drug
-
Paragraph 0155-0157, (2018/02/04)
The invention belongs to the field of medicines and discloses a longistyline analogue and an application thereof in preparation of an antibacterial drug. The longistyline analogue has a structure as shown in the formula I described in the specification, w
Stereoselective synthesis of hydroxy stilbenoids and styrenes by atom-efficient olefination with thiophthalides
Mitra, Prithiba,Shome, Brateen,Ranjan De, Saroj,Sarkar, Anindya,Mal, Dipakranjan
supporting information, p. 2742 - 2752 (2012/11/07)
The synthesis of stilbenoids and styryl carboxylic acids is accomplished with high E-stereoselectivity by olefination of aldehydes with thiophthalides under basic conditions. The olefination is highly atom-efficient as it only loses elemental sulfur during the reaction. This olefination, in conjunction with retro Kolbe-Schmitt reaction, allows facile synthesis of E-hydroxystilbenoids with minimal employment of protecting groups. This study also discloses two important findings: formation of i) 4-methylsulfanyl isocoumarins and ii) an 2-arylindenone. The Royal Society of Chemistry 2012.
