149739-32-2

Basic information

• Product Name: 1H-Pyrazole,3-(2-fluorophenyl)-(9CI)
• Synonyms: 1H-Pyrazole,3-(2-fluorophenyl)-(9CI);5-(2-fluorophenyl)-1H-pyrazole
• CAS NO: 149739-32-2
• Molecular Formula: C₉H₇FN₂
• Molecular Weight: 162.1636832
• Product Categories: HALIDE
• Mol File: 149739-32-2.mol

Chemical Properties

• Melting Point: 58-61℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Pyrazole,3-(2-fluorophenyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole,3-(2-fluorophenyl)-(9CI)(149739-32-2)
• EPA Substance Registry System: 1H-Pyrazole,3-(2-fluorophenyl)-(9CI)(149739-32-2)

Safety Data

• Hazardous Substances Data: 149739-32-2(Hazardous Substances Data)

Usage

Structure

Pyrazole derivative with a 2-fluorophenyl substituent

Potential applications

Pharmaceutical, agrochemical, and material science industries

Biological and chemical activities

Diverse

Usage

Building block for the synthesis of novel compounds with potential biological activity

Suitability for research and development

High (due to the presence of the fluorine atom and phenyl group in its structure)

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 197093-16-6 N-tosyl-N-propargylhydrazine 
• 924287-89-8 (Z)-3-(dimethylamino)-1-(3-fluorophenyl)prop-2-en-1-one 
• 445-27-2 2'-Fluoroacetophenone 

Downstream Products

• 2458-26-6 3-phenylpyrazole 
• 924287-90-1 3-(2-fluorophenyl)-1-methylpyrazole 
• 924287-91-2 1-methyl-5-(2-fluorophenyl)pyrazole 
• 1599475-08-7 2-fluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)-6-methylbenzamide 
• 1599475-07-6 2,6-difluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide 
• 1599475-06-5 2,3,6-trifluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide 
• 1599475-30-5 C₁₄H₁₂FN₃S 
• 1599475-29-2 C₁₄H₁₀FN₃O₂S 
• 1599475-05-4 2,4,6-trifluoro-N-(5-(3-(2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)thiophen-2-yl)benzamide 
• 1361380-62-2 C₁₃H₁₁FN₄S 
• 1361379-71-6 2,6-difluorophenyl-N-{5-[3-(2-fluorophenyl)-1-methylpyrazol-5-yl](1,3-thiazol-2-yl)}carboxamide 
• 1361379-40-9 N-(2,6-difluorophenyl){5-[3-(2-fluorophenyl)-1-methylpyrazol-5-yl](2-thienyl)}carboxamide 
• 1345118-65-1 N-{5-[3-(2-fluorophenyl)-1-methylpyrazol-5-yl](2-pyridyl)}(2,6-difluorophenyl)carboxamide 
• 1345118-71-9 5-(1-methyl-3-(2-fluorophenyl)pyrazol-5-yl)-2-pyridylamine 

Relevant articles and documents

BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of Formula (I), or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: (a); (b); (c); or (d), further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also discl

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.

Functionalised Pyrazoles through a Facile One-Pot Procedure from N-Tosyl-N-propargylhydrazine and Aryl Iodides or Vinyl Triflates

Functionalised pyrazoles have been prepared in good overall yield through a facile one-pot procedure. The synthesis includes the palladium-catalysed coupling of the readily available N-tosyl-N-propargylhydrazine with aryl iodides or vinyl triflates, the palladium-catalysed annulation of the resulting N-tosyl-N-(1-aryl/vinyl-1-propyn3-yl)hydrazine and exposure of the reaction mixture arising from the annulation step to KOBut.