149771-23-3

Basic information

• Product Name: 5-Pyrimidinecarboxylicacid,2-amino-4-(trifluoromethyl)-(9CI)
• Synonyms: 5-Pyrimidinecarboxylicacid,2-amino-4-(trifluoromethyl)-(9CI);5-Pyrimidinecarboxylic acid, 2-amino-4-(trifluoromethyl)-
• CAS NO: 149771-23-3
• Molecular Formula: C6H4F3N3O2
• Molecular Weight: 207.111
• Product Categories: AMINOACID
• Mol File: 149771-23-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.5oC at 760 mmHg
• Flash Point: 205.7oC
• Appearance: /
• Density: 1.667g/cm3
• Vapor Pressure: 1.11E-07mmHg at 25°C
• Refractive Index: 1.533
• PKA: 2.45±0.36(Predicted)
• CAS DataBase Reference: 5-Pyrimidinecarboxylicacid,2-amino-4-(trifluoromethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylicacid,2-amino-4-(trifluoromethyl)-(9CI)(149771-23-3)
• EPA Substance Registry System: 5-Pyrimidinecarboxylicacid,2-amino-4-(trifluoromethyl)-(9CI)(149771-23-3)

Safety Data

• Statements: 20/21/22-37/38-48
• Safety Statements: 7/8-22-26-36/37/39-45
• Hazardous Substances Data: 149771-23-3(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow powder

InChI:InChI=1/C6H4F3N3O2/c7-6(8,9)3-2(4(13)14)1-11-5(10)12-3/h1H,(H,13,14)(H2,10,11,12)

Upstream product

• 149771-09-5 ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate 
• 1048670-08-1 2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester 

Relevant articles and documents

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Synthesis, antiviral (HSV-1) and antimycotic activities of ethyl or methyl 2,4-disubstituted 5-pyrimidinecarboxylates, 2,4-disubstituted 5-pyrimidinecarboxylic acids and 2,4-disubstituted pyrimidines

The synthesis of ethyl or methyl 4-substituted or unsubstituted 2-methylthio-5-pyrimidinecarboxylates 3 a-i and 8 o mainly by reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with 2-methylisothiourea is described. Also some ethyl 2-sub