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149771-09-5

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149771-09-5 Usage

Description

ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is a pyrimidine derivative with the molecular formula C8H8F3N3O2, featuring an ethyl ester group. This white to off-white solid is widely utilized in organic synthesis and pharmaceutical research, and is recognized for its potential as an antiviral and anticancer agent due to its enzyme and pathway inhibition capabilities.

Uses

Used in Pharmaceutical Research:
ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is used as an intermediate in the synthesis of various pharmaceutical compounds and research chemicals, contributing to the development of new drugs and therapies.
Used in Organic Synthesis:
In the field of organic synthesis, ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE serves as a key component in the creation of complex organic molecules, facilitating advancements in chemical research and product development.
Used in Antiviral Applications:
ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is used as an antiviral agent for its ability to inhibit specific enzymes and pathways, potentially leading to the development of treatments for viral infections.
Used in Anticancer Applications:
ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE is used as an anticancer agent, leveraging its capacity to interfere with cellular processes in cancer cells, thus offering a potential therapeutic approach in oncology.

Check Digit Verification of cas no

The CAS Registry Mumber 149771-09-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,7,7 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 149771-09:
(8*1)+(7*4)+(6*9)+(5*7)+(4*7)+(3*1)+(2*0)+(1*9)=165
165 % 10 = 5
So 149771-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8F3N3O2/c1-2-16-6(15)4-3-13-7(12)14-5(4)8(9,10)11/h3H,2H2,1H3,(H2,12,13,14)

149771-09-5 Well-known Company Product Price

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  • Alfa Aesar

  • (B20724)  Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate, 97%   

  • 149771-09-5

  • 1g

  • 358.0CNY

  • Detail
  • Alfa Aesar

  • (B20724)  Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate, 97%   

  • 149771-09-5

  • 5g

  • 1383.0CNY

  • Detail
  • Alfa Aesar

  • (B20724)  Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate, 97%   

  • 149771-09-5

  • 25g

  • 5862.0CNY

  • Detail

149771-09-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ETHYL 2-AMINO-4-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE

1.2 Other means of identification

Product number -
Other names Ethyl 2-amino-4-(trifluoromethyl)pyrimidine-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149771-09-5 SDS

149771-09-5Relevant articles and documents

The reactions of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole as a way to novel azaheterocycles

Goryaeva, Marina V.,Burgart, Yanina V.,Ezhikova, Marina A.,Kodess, Mikhail I.,Saloutin, Viktor I.

, p. 385 - 391 (2015)

The interaction of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole is an efficient synthetic approach to novel azaheterocycles. 2-Ethoxymethylidene-3-oxo esters bearing alkyl substituents react with 5-aminotetrazole to form ethyl 2-azido-4-alkylpyrimidine-5-carboxylates which are capable of subsequent nucleophilic substitution. The use of diethyl 2-ethoxymethylidenemalonate in this reaction resulted in ethyl 7-hydroxytetrazolo[1,5-a]pyrimidine-6-carboxylate, while ethyl 2-ethoxymethylidenecyanoacetate yielded 5-[2,6-diamino-3,5-bis(ethoxycarbonyl)pyridinium-1-yl]tetrazol-1-ide through an alternative pathway. Ethyl 2-benzoyl-3-ethoxyprop-2-enoate reacted with 5-aminotetrazole by two reaction routes to form ethyl 2-benzoyl-3-(1H-tetrazol-5-ylamino)prop-2-enoate and ethyl 7-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-yl)-5-phenyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate.

Reaction of 2-(ethoxymethylidene)-3-oxo carboxylic acid esters with tetrazol-5-amine

Goryaeva,Burgart,Ezhikova,Kodess,Saloutin

, p. 992 - 1002 (2015)

2-(Ethoxymethylidene)-3-oxo carboxylic acid esters reacted with tetrazol-5-amine to give ethyl 4-alkyl-2-azidopyrimidine-5-carboxylates capable of undergoing subsequent nucleophilic substitution of hydrogen on C6 or azido group. The reaction of ethyl 2-benzoyl-3-ethoxyprop-2-enoate with tetrazol-5-amine was accompanied by partial decomposition to afford a mixture of ethyl 3-oxo-3-phenylpropanoate and ethyl 7-(1-ethoxy-1,3-dioxo-3-phenylpropan-2-yl)-5-phenyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate. Ethyl 7-hydroxytetrazolo[1,5-a]pyrimidine-6-carboxylate was formed as a result of cyclization of diethyl 2-(ethoxymethylidene)propanedioate with tetrazol-5-amine.

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate: An inhibitor of AP-1 and NF-κB mediated gene expression

Palanki, Moorthy S.S.,Gayo-Fung, Leah M.,Shevlin, Graziella I.,Erdman, Paul,Sato, Mark,Goldman, Mark,Ransone, Lynn J.,Spooner, Cheryl

, p. 2573 - 2577 (2007/10/03)

Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine- 5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)- pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.

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