149774-38-9Relevant academic research and scientific papers
SELENIUM-CONTROLLED STEREOSELECTIVE SYNTHESIS OF 2'-DEOXYNUCLEOSIDES FROM GLYCALS. A FORMAL SYNTHESIS OF AZT
El-Laghdach, Anas,Diaz, Yolanda,Castillon, Sergio
, p. 2821 - 2822 (1993)
2'-Deoxynucleosides have been stereoselectively synthesized starting from glycals, using phenylselenyl reagents.Key Words: 2'-Deoxynucleosides, stereoselective glycosylation, glycals.
Synthesis of 2'-deoxy-2'-phenylselenenyl-furanosyl nucleosides from glycals using electrophilic selenium reagents. Conversion into 2'-deoxynucleosides
Diaz, Yolanda,El-Laghdach, Anas,Castillon, Sergio
, p. 10921 - 10938 (2007/10/03)
2'-Deoxy-2'-phenylselenenyl-furanosyl nucleosides have been synthesized stereoselectively from glycals using selenium reagents, and converted into 2'-deoxynucleosides by treatment with tributyltin hydride. Some of the factors which affect the stereoselectivity of the reaction are the stereochemistry at position 3, the nature of the protecting groups, the phenylselenenyl reagent and the solvent.
