1498-46-0

Usage

Uses

Used in Chemical Synthesis:
ISOPROPYL PHOSPHONIC DICHLORIDE is used as a chemical intermediate for the preparation of bis(fluoroalkyl) alkylphosphonates. It reacts with fluoroalcohols in the presence of triethylamine as a catalyst, which is crucial for the formation of these specific phosphonate compounds.
Used in Pharmaceutical Industry:
ISOPROPYL PHOSPHONIC DICHLORIDE is used as a building block in the synthesis of various pharmaceutical compounds. Its reactivity and versatility make it a valuable component in the development of new drugs and therapeutic agents.
Used in Material Science:
In the field of material science, ISOPROPYL PHOSPHONIC DICHLORIDE is utilized as a precursor for the development of novel materials with specific properties, such as improved thermal stability or enhanced chemical resistance.
Used in Agrochemical Industry:
ISOPROPYL PHOSPHONIC DICHLORIDE is employed as a starting material for the synthesis of various agrochemicals, including pesticides and herbicides. Its role in these applications is to provide a stable and effective active ingredient for controlling pests and weeds in agricultural settings.

InChI:InChI=1/C3H7Cl2OP/c1-3(2)7(4,5)6/h3H,1-2H3

Upstream product

• 540-54-5 1-Chloropropane 
• 75-29-6 isopropyl chloride 
• 74-98-6 propane 
• 25235-15-8 dichloroisopropylphosphine 
• 1538-69-8 diethyl isopropylphosphonate 
• 7446-70-0 aluminium trichloride 
• 7719-12-2 phosphorus trichloride 

Downstream Products

• 4721-37-3 isopropylphosphonic acid 
• 21657-93-2 5-isopropyl-2,8-diphenyl-5,6-dihydro-4H-[1,3,4,6,7,5]oxatetrazaphosphocine 5-oxide 
• 54552-74-8 Isopropylphosphonsaeurephenylesterchlorid 
• 123872-80-0 Isopropyl-phosphonic acid bis-(2,5-dimethyl-phenyl) ester 
• 123872-81-1 Isopropyl-phosphonic acid bis-(3,4-dimethyl-phenyl) ester 
• 38873-93-7 Isopropyl-phosphonic acid bis-(4-nitro-phenyl) ester 
• 123872-84-4 Isopropyl-phosphonic acid dipentachlorophenyl ester 
• 123872-74-2 Isopropyl-phosphonic acid di-p-tolyl ester 
• 84549-34-8 2-isopropyl-4-methyl-1,3,2-dioxaphospholane-2-oxide 
• 123872-76-4 O,O-bis(4-t-butylphenyl) isopropyl phosphonate 
• 123872-68-4 Isopropyl-phosphonic acid bis-(2-chloro-phenyl) ester 
• 123872-78-6 Isopropyl-phosphonic acid bis-(2,3-dimethyl-phenyl) ester 
• 123872-77-5 Isopropyl-phosphonic acid bis-(4-methylsulfanyl-phenyl) ester 
• 123872-82-2 O,O-bis(2,3,5-trimethylphenyl) isopropyl phosphonate 

Relevant academic research and scientific papers

A novel and efficient synthesis of N,N-dialkylaminoisopropyl- and O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene)phosphonohydrazido oximes - Potential marine fish toxin analogues. Part 1

A novel and efficient method for the synthesis of N,N- dialkylaminoisopropyland O-alkylisopropyl-2-(1-alkyl-2-oxopropylidene) phosphonohydrazido oximes (4) using activated silica as dehydrating agent has been developed. The reaction involves the condensat

A Library of Well-Defined and Water-Soluble Poly(alkyl phosphonate)s with Adjustable Hydrolysis

Poly(alkyl ethylene phosphonate)s with different alkyl side chains exhibit significant differences in their degradation behavior. Three novel 2-alkyl-2-oxo-1,3,2-dioxaphospholanes, cyclic monomers for the ring-opening polymerization (ROP) toward poly(alkyl alkylene phosphonate)s, were synthesized by robust two- or three-step protocols in reasonable yields and high purity. The polymerization was promoted by the organocatalysts 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and proceeded with high control over molecular weight and narrow molecular weight distributions (A 1.2) up to full conversion. These polymers with methyl, ethyl, and isopropyl side chains are perfectly soluble in water (up to 25 mg mL-1) without a temperature-dependent phase separation. They showed no toxicity against HeLa cells after 24 h of incubation at any tested concentration. Polymers with butyl side chains exhibit decreased solubility and concentration-dependent cloud point temperatures and show toxicity against HeLa cells at concentrations above 25 mL-1. The polymers showed no acetylcholinesterase inhibition. All polymers exhibited significantly different degradation times under both neutral as well as basic conditions (variation of the alkyl side chain allowed stabilities from 8 h up to 6 days).

Easy preparation of alkylphosphonyl dichlorides

Phosphonic acid esters bearing an alkyl, halogen or carboxylate substituent on the α-carbon are readily converted into the parent phosphonic dichlorides when treated with a mixture of 2.5 eq of phosphorus pentachloride and 1.3 eq of phosphorus oxychloride.Keywords - phosphonates / chlorination / phosphorus pentachloride / phosphorus oxychloride / phosphonyl dichloride