1498-64-2

Basic information

• Product Name: ETHYL DICHLOROTHIOPHOSPHATE
• Synonyms: ETHYL DICHLOROTHIOPHOSPHATE;ETHYL PHOSPHORODICHLORIDOTHIONATE;(dichloroethoxy)phosphinesulfide;dichloroethoxy-phosphinesulfid;Ethoxythiophosphorylchloride;ethyldichlorthiofosfat;ethylphosphorothioicdichloride;monoethyldichlorothiophosphate
• CAS NO: 1498-64-2
• Molecular Formula: C₂H₅Cl₂OPS
• Molecular Weight: 179.01
• EINECS: 216-100-4
• Product Categories: Phosphorylating Agents;Building Blocks;Chemical Synthesis;Organic Building Blocks;Phosphorus Compounds
• Mol File: 1498-64-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 55-68 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.353 g/mL at 25 °C(lit.)
• Vapor Pressure: 10 mm Hg ( 55 °C)
• Refractive Index: n20/D 1.504(lit.)
• CAS DataBase Reference: ETHYL DICHLOROTHIOPHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL DICHLOROTHIOPHOSPHATE(1498-64-2)
• EPA Substance Registry System: ETHYL DICHLOROTHIOPHOSPHATE(1498-64-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-34-23/24-22
• Safety Statements: 22-26-36/37/39-45
• RIDADR: UN 3390 6.1/PG 1
• WGK Germany: 3
• RTECS: TD4400000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 1498-64-2(Hazardous Substances Data)

Usage

Uses

Ethyl Dichlorothiophosphate is used in the preparation of polyclonal antibody for insecticide chlorpyrifos. It is also used in the mutagenicity study of new organophosphorus pesticides.

InChI:InChI=1/C2H5Cl2OPS/c1-2-5-6(3,4)7/h2H2,1H3

Upstream product

• 3982-91-0 trichlorothiophosphine 
• 64-17-5 ethanol 
• 555-75-9 aluminum ethoxide 

Downstream Products

• 18351-18-3 O-ethyl-O-(2,4-dichlorophenyl)thiophosphorochloride 
• 86801-05-0 O-ethyl-O-phenyl-phosphorochloridothioate 
• 1089310-25-7 (2S,4S,5R)-2-ethoxy-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione 
• 57573-34-9 (4S)-2-ethoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide 
• 97531-36-7 2-Ethoxy-3,4,5-triphenyl-3H-[1,3,2]oxazaphosphole 2-sulfide 
• 97531-37-8 2-Ethoxy-4,5-diphenyl-3-p-tolyl-3H-[1,3,2]oxazaphosphole 2-sulfide 
• 142559-66-8 3-ethoxy-2,4,6,7-tetraphenyl-3-thioxo-P-1,5,3-diazaphosphepine 
• 135245-94-2 6-(2,4-Dichloro-phenyl)-2-ethoxy-[1,2,4]triazolo[4,3-d][1,3,4,2]thiadiazaphosphole 2-sulfide 
• 81581-15-9 (2R,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione 
• 81623-63-4 (2S,4R,5S)-2-ethoxy-4-methyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione 
• 460-53-7 Difluorothiophosphorsaeure-ethylester 
• 460-51-5 thiophosphorochloridofluoridic acid O-ethyl ester 
• 71348-06-6 ethyl methyl chlorothiophosphate 
• 109731-21-7 diethyl N-(phenylhydrazino)amidothiophosphate 

Relevant articles and documents

Studies on chiral thiophosphoric acids and their derivatives 14. The asymmetric cyclization of (+)-cis-1,2,2-trimethyl-1,3-diaminocyclopentane with thiophosphorodichloridates and o-(4-nitrophenyl)thiophosphorochloridates

The cyclization of (+)-cis-1,2,2-trimethyl-1,3-diaminocyclopentane 1 with thiophosphorodichloridates 2 or O-(4-nitrophenyl)thiophosphorochloridates 4 forms (+)-2,4,5-diazaphosphabicyclo[3.2.1]octane 3 and 3′, respectively, but the stereoselectivity arising from the condensation of (+)-1 with 4 is less than that of (+)-1 with 2. The distinction between the two product distributions might be due to the significance of different mechanistic routes. In the light of a trigonal bipyramid (TBP) intermediate and Berry pseudorotation (BPR) concept their mechanism are discussed.

Preparation methods of methyl ethyl thiophosphoryl chloride and methyl ethyl chlorpyrifos

The invention provides a preparation method of methyl ethyl thiophosphoryl chloride and relates to the field of chemical synthesis. Thiophosphoryl chloride is adopted as an initial raw material and reacts with ethyl alcohol to obtain an intermediate A; the intermediate A reacts with sodium methoxide to obtain the methyl ethyl thiophosphoryl chloride. The preparation method is simple to operate, raw materials are easy to obtain, reaction conditions are mild, and the methyl ethyl thiophosphoryl chloride can be obtained with high efficiency and high yield only through the simple two-step reaction. The invention further provides a preparation method of methyl ethyl chlorpyrifos; the methyl ethyl thiophosphoryl chloride is prepared by adopting the preparation method of the methyl ethyl thiophosphoryl chloride and then reacts with sodium trichloro pyridinol to obtain the methyl ethyl chlorpyrifos. The preparation method is simple and convenient to operate and low in requirements for equipment and can realize the scale production of the methyl ethyl chlorpyrifos.

Preparation and activity study of a new organophosphate insecticidals

A new organophosphorus pesticide, compound 2 was prepared. The laboratory evaluations against Plutella xylostella L larva was performed. This compound showed the similar toxicity with corresponding pesticides but with higher insecticidal activity.

Synthesis of novel chiral 2-Oxo- And 2-thio-1,3,2-oxazaphospholidines via asymmetric cyclization of L-methionol with (thio)phosphoryl dichlorides

In order to search for novel antitumor and antiviral agents with high activity and low toxicity, a series of chiral 2-thio(oxo)-1,3,2- oxazaphospholidines were synthesized via the reaction of L-methionol with all kinds of (thio)phosphoryl dichlorides in THF in the presence of triethylamine at room temperature. The structures of all of the new compounds were confirmed by elemental analyses, 1H, 31P NMR, and 1R spectra.