149846-39-9

Upstream product

• 64-17-5 ethanol 
• 149846-41-3 (2S,3S)-2-Hydroxy-3-(toluene-4-sulfonyloxy)-succinic acid diisobutyl ester 
• 149884-12-8 diethyl (2S,3S)-2-hydroxy-3-(4-methylphenylsulfonyloxy)butane-1,4-dioate 
• 149884-09-3 bis(2-methylpropyl) (2S,3S)-2,3-dihydroxybutane-1,4-dioate 
• 13811-71-7 diethyl (2S,3S)-tartrate 
• 78-83-1 2-methyl-propan-1-ol 

Downstream Products

• 149846-44-6 ethyl 2-methylpropyl (2S,3S)-2-tert-butyldimethylsilyloxy-3-(4-methylphenylsulfonyloxy)butane-1,4-dioate 

Relevant academic research and scientific papers

Applications of Biotransformations in Organic Synthesis: Preparation of Enantiomerically Pure Esters of cis- and trans-Epoxysuccinic Acid

Chemical and enzymatic procedures have been investigated for the resolution of esters of trans-epoxysuccinic acid (trans-oxirane-2,3-dicarboxylic acid).A successful resolution was achieved by transesterification of the diethyl ester against heptanol catalysed by the lipase from Rhizopus javanicus.Asymmetrization of cis-epoxysuccinic acid was achieved by enantioselective and regiospecific hydrolysis of the racemic diethyl ester of 2-(toluene-p-sulfonyloxy)tartaric acid , followed by esterification with 2-methylpropanol and oxirane formation.