149918-92-3Relevant academic research and scientific papers
Synthesis of 123I and 125I-labelled 5-iodo-6-nitroquipazine
Mathis,Enas,Hanrahan,Akgun
, p. 905 - 913 (1994)
The syntheses of the potent and selective serotonin reuptake complex radioligands [123I]- and [125I]5-iodo-6-nitroquipazine (5-iodo-6-nitro-2-piperazinylquinoline) are reported. A seven step synthetic sequence provided the BOC-protected 5-tributyltin-6-nitroquipazine precursor for radioiodination. End of synthesis radioiodination yields of -40% for 123I and ~ 60% for 125I were achieved resulting in labelled products with high specific activities (>4000 and >2000 Ci/mmol, respectively) and radiochemical purities (>98%).
