1499198-33-2

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 2689-61-4 (2-oxo-2-p-tolylethyl)triphenylphosphonium bromide 
• 1245905-84-3 (E)-4,4,4-trifluoro-3-phenyl-1-(4-methylphenyl)-2-buten-1-one 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 

Relevant academic research and scientific papers

Benzylamine as Hydrogen Transfer Agent: Cobalt-Catalyzed Chemoselective C=C Bond Reduction of β-Trifluoromethylated α,β-Unsaturated Ketones via 1,5-Hydrogen Transfer

An efficient cobalt-catalyzed chemoselective reduction of β-CF3-α,β-unsaturated ketones using benzylamine as hydrogen transfer agent involving intramolecular 1,5-hydrogen transfer is reported. The reaction proceeded smoothly with a relatively w

Method of reducing beta-CF3 substituted alpha,beta-unsaturated ketones

The invention relates to a method of reducing beta-CF3 substituted alpha,beta-unsaturated ketones. Benzylamine or substituted benzylamine is in the method for the first time as an intramolecular 1,5-hydrogen transfer agent; under promotion of Lewis acid m

Base-Catalyzed Stereospecific Isomerization of Electron-Deficient Allylic Alcohols and Ethers through Ion-Pairing

A mild base-catalyzed strategy for the isomerization of allylic alcohols and allylic ethers has been developed. Experimental and computational investigations indicate that transition metal catalysts are not required when basic additives are present. As in the case of using transition metals under basic conditions, the isomerization catalyzed solely by base also follows a stereospecific pathway. The reaction is initiated by a rate-limiting deprotonation. Formation of an intimate ion pair between an allylic anion and the conjugate acid of the base results in efficient transfer of chirality. Through this mechanism, stereochemical information contained in the allylic alcohols is transferred to the ketone products. The stereospecific isomerization is also applicable for the first time to allylic ethers, yielding synthetically valuable enantioenriched (up to 97% ee) enol ethers.

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

Regioselective conjugate 1,4-trifluoromethylation of α,β- unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into β- trifluoromethylated ketones in low to moderate yields.