149946-67-8

Basic information

• Product Name: 3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol
• Synonyms: 3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol
• CAS NO: 149946-67-8
• Molecular Weight: 231.064
• Mol File: 149946-67-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol(149946-67-8)
• EPA Substance Registry System: 3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol(149946-67-8)

Safety Data

• Hazardous Substances Data: 149946-67-8(Hazardous Substances Data)

Usage

Chemical compound

3-(4-Bromo-2-fluorophenyl)-2-propen-1-ol

Chemical class

alkene

Functional groups

phenyl and propenol

Atoms present

bromine and fluorine

Uses

synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Potential applications

materials science and industrial processes

Precautions

proper handling and safety measures required for working with the compound

Upstream product

• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 581778-88-3 (E)-ethyl 3-(4-bromo-2-fluorophenyl)acrylate 
• 575469-65-7 3-(4-bromo-2-fluorophenyl)-2-propenoic acid 

Relevant articles and documents

A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3-Phenylallyl Ethers

A transition-metal-free Claisen rearrangement/cyclization reaction was developed for the synthesis of naphthofuran derivatives from bromonaphthyl 3-phenylallyl ethers. The nature of the base employed in this reaction plays an important role in determining the ratio for the formation of naphthofuran and naphthol products. By using K2CO3 as base and DMF as solvent, we have synthesized a variety of functionalized naphthofurans in good to high yields (49-92 %) and with satisfactory selectivities.

3,4-dihydro-4-oxo-3-(2-propenyl)-1-phthalazineacetic acids and derivatives, their preparations and medicines containing them

Novel 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetic acids and derivatives of formula (I) STR1 in which R1 R2 and R3 are the same or different and stand for H, a halogen or a linear or branched aliphatic, saturated or unsaturated radical, substituted or not by at least one halogen or R4 residue such as defined below, except when R4 is H; R4 and R5 are the same or different and stand for H, a linear or branched aliphatic radical, saturated or unsaturated, an aryl or heteroaryl radical, said radicals being substituted or not by at least one grouping such as fluorine, chlorine, bromine, methyl or trifluoromethyl, where R4 and R5 do not simultaneously denote H; R6 stands for hydroxy or alkoxy radical; R7 stands for H, a halogen, a linear or branched aliphatic saturated or unsaturated radical, an alkoxy radical, said radicals being substituted or not by analiphatic or halogenated radical, a nitro group, a substituted or unsubstituted amino group, S(O)n R8 or a cyano group; n is equal to 0,1 or 2; R8 is an aliphatic, linear or branched radical, an aryl or heteroaryl radical, an amino radical, said radicals being substituted or not by an aliphatic or halogenated radical. This invention also relates to the optional tautomeric forms of said acids and their pharmaceutically acceptable base addition salts. Also described is a process for preparing said compounds and the drugs containing same.