149968-10-5

Basic information

• Product Name: 1-{3-(1E)-2-(7-Chloro(2-Quinolyl))Vinylphenyl}Prop-2-En-1-Ol
• Synonyms: BenzeneMethanol,3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]-a-ethenyl-;1-{3-(1E)-2-(7-Chloro(2-Quinolyl))Vinylphenyl}Prop-2-En-1-Ol;(E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)prop-2-en-1-ol;1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]prop-2-en-1-ol
• CAS NO: 149968-10-5
• Molecular Formula: C₂₀H₁₆ClNO
• Molecular Weight: 321.80014
• Mol File: 149968-10-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 504.125°C at 760 mmHg (Cal.) ref.
• Flash Point: 258.686°C (Cal.) ref.
• Appearance: /
• Density: 1.264g/cm3 (Cal.) ref.
• Storage Temp.: 2-8°C
• PKA: 13.47±0.20(Predicted)
• CAS DataBase Reference: 1-{3-(1E)-2-(7-Chloro(2-Quinolyl))Vinylphenyl}Prop-2-En-1-Ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{3-(1E)-2-(7-Chloro(2-Quinolyl))Vinylphenyl}Prop-2-En-1-Ol(149968-10-5)
• EPA Substance Registry System: 1-{3-(1E)-2-(7-Chloro(2-Quinolyl))Vinylphenyl}Prop-2-En-1-Ol(149968-10-5)

Safety Data

• Hazardous Substances Data: 149968-10-5(Hazardous Substances Data)

Usage

Uses

(E)-1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-propen-1-ol is a useful synthetic intermediate in the synthesis of L-699392, a LTD4 antagonist.

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 626-19-7 Isophthalaldehyde 
• 4965-33-7 2-methyl-7-chloroquinoline 
• 3536-96-7 vinylmagnesium chloride 
• 120578-03-2 (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde 
• 7732-18-5 water 

Downstream Products

• 149968-11-6 methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate 
• 203940-08-3 1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propenone 
• 904916-16-1 4-chloro-N-(3-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-3-oxopropyl)benzenesulfonamide 
• 203940-38-9 (+/-)-4-chloro-N-(3-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-3-hydroxypropyl)benzenesulfonamide 
• 904916-17-2 (+/-)-4-chloro-N-(3-chloro-3-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)benzenesulfonamide 
• 203940-29-8 (+/-) methyl 3-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]propionate 
• 904916-18-3 (+/-) ethyl 2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]acetate 
• 904916-19-4 (+/-) methyl 4-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]butyrate 
• 203940-39-0 (+/-) methyl 4-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]-3,3-dimethylbutyrate 
• 904916-21-8 (+/-) methyl 4-{[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]methyl}benzoate 
• 904916-22-9 (+/-) methyl 4-{[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]methyl}phenylacetate 
• 904916-23-0 (+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate 
• 904916-20-7 [1-(3-(4-Chloro-benzenesulfonylamino)-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propylsulfanylmethyl)-cyclopropyl]-acetic acid benzyl ester 
• 150026-73-6 -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone 

Relevant articles and documents

Continuous recycling of homogeneous Pd/Cu catalysts for cross-coupling reactions

Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist "Singulair" with efficient continuous homogeneous catalyst recycling.

AN IMPROVED PROCESS FOR THE PREPARATION OF MONTELUKAST SODIUM AND ITS INTERMEDIATES

The present invention relates to a process for the preparation of montelukast sodium (formula 1) and formula 4. The invention concerns the coupling of thiol derivative, Methyl 1 - (mercaptomethyl)cyclopropane acetate with mesylate of formula 4 compound using alkyl substituted ammonium hydroxide base, alkali amides and purification of Montelukast acid by crystallization in suitable organic solvents. The invention further concerns to provide an improved process of montelukast intermediates having good yield and quality

PREPARATION OF MONTELUKAST AND ITS SALTS

There is provided a process for the preparation of montelukast of the Formula (I).