150026-72-5

Basic information

• Product Name: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester
• Synonyms: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester;[R-(E)]-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl;2-[(3R)-3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester;Montelukast (3R)-Hydroxy Benzoate;Montelukast Related Impurity 3;2-[(3R)-(2-(7-Chloro-2-quinolinyl)-ethenyl-phenyl)-3-hydroxy-propyl)]-1-methoxycarbonylbenzene
• CAS NO: 150026-72-5
• Molecular Formula: C₂₈H₂₄ClNO₃
• Molecular Weight: 457.94806
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 150026-72-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 643.972°C at 760 mmHg
• Flash Point: 343.262°C
• Appearance: /
• Density: 1.279g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.687
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• PKA: 14.06±0.20(Predicted)
• CAS DataBase Reference: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester(150026-72-5)
• EPA Substance Registry System: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester(150026-72-5)

Safety Data

• Hazardous Substances Data: 150026-72-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Foam

Uses

An intermediate in the synthesis of (S)-Montelukast.

InChI:InChI=1/C28H24ClNO3/c1-33-28(32)25-8-3-2-6-20(25)12-16-27(31)22-7-4-5-19(17-22)9-14-24-15-11-21-10-13-23(29)18-26(21)30-24/h2-11,13-15,17-18,27,31H,12,16H2,1H3/b14-9+/t27-/m1/s1

Upstream product

• 133791-17-0 2-(3-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-oxopropyl)benzoic acid methyl ester 
• 149968-11-6 methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate 
• 120578-03-2 (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 149968-10-5 (E)-3-<2-(7-chloro-2-quinolinyl)ethenyl>-α-ethenylphenylmethanol 

Downstream Products

• 150026-75-8 (2-(2-(3-(3(R)-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propanol) 
• 142393-03-1 2-(3(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-((3-hydroxy-3-methylbutyl)thio)propyl)benzoic acid 
• 150026-73-6 -1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone 
• 855473-47-1 2-((R)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-3-methanesulfonyloxy-propyl)-benzoic acid methyl ester 
• 158966-92-8 montelukast 
• 851755-56-1 [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]thio]methyl]-cyclopropane acetic acid 

Relevant articles and documents

SYTHESIS OF OPTICALLY ACTIVE INTERMEDIATE FOR THE PREPARATION OF MONTELUKAST

The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general f

PREPARATION OF MONTELUKAST AND ITS SALTS

There is provided a process for the preparation of montelukast of the Formula (I).

Process for preparation of montelukast and its salts

A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl) vinyl [phenyl]-3-[2-methoxy carbonyl phenyl] propyl sulfonyl methyl] cyclo propyl] acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl) benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.