150007-96-8

Basic information

• Synonyms: Benzoic acid, 4-amino-5-chloro-2-methoxy-, anhydride with ethyl hydrogen carbonate (9CI)
• CAS NO: 150007-96-8
• Molecular Formula: C₁₁H₁₂ClNO₅
• Molecular Weight: 273.67
• Mol File: 150007-96-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(150007-96-8)
• EPA Substance Registry System: N/A(150007-96-8)

Safety Data

• Hazardous Substances Data: 150007-96-8(Hazardous Substances Data)

Upstream product

• 20896-27-9 methyl 4-amino-5-chloro-2-methoxybenzoate 
• 7206-70-4 4-amino-5-chloro-2-methoxybenzoic acid 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 122892-34-6 4-amino-5-chloro-N-<4-<2-(dimethylamino)ethoxy>benzyl>-2-methoxybenzamide 
• 287399-47-7 butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate 
• 768370-78-1 4-(4-amino-5-chloro-2-methoxy-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester 
• 81098-60-4 (+)-(3S,4R)-cisapride 
• 145726-56-3 4-amino-5-chloro-2-methoxy-N-(1-trityl-4-piperidyl)benzamide 
• 169451-72-3 (S)-(+)-4-amino-N-(1-benzyl-3-pyrrolidinyl)-5-chloro-2-methoxybenzamide 
• 364-62-5 metoclopramide 

Relevant articles and documents

An improved synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224)

A new and facile route for the synthesis of the novel gastrointestinal prokinetic butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (1b), which exhibited potent gastro- and colon-prokinetic activities by oral administration without significant side effects, was established. The key intermediate, butyl 4-amino-1-piperidineacetate (16), was prepared from commercially available 4-amino-1-benzylpiperidine (2) in a high yield with four steps. Compound 1b was prepared by condensation of commercially available 4-amino-5-choloro-2-methoxybenzoic acid (7) with 16 in 84% yield. This improved synthetic route was appropriate for large-scale synthesis of 1b.

Improved synthesis and application of [11C]benzyl iodide in positron emission tomography radiotracer production

Positron emission tomography has increased the demand for new carbon-11 radiolabeled tracers and building blocks. A promising radiolabeling synthon is [11C]benzyl iodide ([11C]BnI), because the benzyl group is a widely present functi

Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT3 ligands

A series of 4-amino-5-chloro-2-methoxybenzoates and benzamides containing the 5- and 6-isoquinuclidinyl system was synthesised and evaluated for binding to 5-HT3, 5-HT4 and D2 receptors. In general, the isoquinuclidine derivatives at the 5-position have shown to be more potent as 5-HT3 ligands but they also possess 5-HT4 and D2 properties. However, the results show that the derivatives at the 6-position afforded the most promising compounds in terms of both receptor affinity and selectivity.