150008-63-2Relevant academic research and scientific papers
Tandem 1,4-Diaza,3-oxa-Cope Rearrangement - Nucleophilic Addition Reaction. A Route to 2-Oxobenzimidazoles.
Saczewski, Franciszek,Debowski, Tomasz
, p. 2843 - 2846 (1993)
A novel tandem 1,4-diaza-3-oxa-Cope rearrangement - nucleophilic addition reaction has been deviced in which the formation of 2-oxobenzimidazoles 9 has been rationalized on the basis of an inital sigmatropic rearrangement of the N-cyanato-anilines 6, followed by an intramolecular nucleophilic addition in the intermediate isocyanates 7.
Synthesis, structure, and biological activities of some N-(4,5-dihydro-1H-imidazol-2-yl)-1,3-dihydrobenzimidazole derivatives
Saczewski, Franciszek,Debowski, Tomasz,Petrusewicz, Jacek,Trzeciak, Henryk,Krzystanek, Ewa,Krzystanek, Marek,Gdaniec, Maria,Nowakowska, Emilia
, p. 241 - 248 (1998)
A series of novel N-(4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole derivatives 2a-d, 3a-d and 4a-p were prepared and their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intravenous administration to normotensive rats.
