150109-58-3

Upstream product

• 129816-30-4 5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine 
• 35424-56-7 1-chloro-4-(iodomethyl)benzene 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 150082-94-3 (S)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 150082-96-5 (R)-2-tert-Butoxycarbonylamino-3-methyl-butyric acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 150083-10-6 tert-Butoxycarbonylamino-acetic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-(2-dimethylamino-acetoxymethyl)-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 179744-30-0 (S)-2-tert-Butoxycarbonylamino-3-phenyl-propionic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 752181-34-3 tert-Butoxycarbonylamino-acetic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-(2-methylamino-acetoxymethyl)-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 765878-52-2 tert-Butoxycarbonylamino-acetic acid 3-[(2R,4S,5R)-5-(2-amino-acetoxymethyl)-4-(4-chloro-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 150082-95-4 (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-{3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl} ester 
• 179744-31-1 3-tert-Butoxycarbonylamino-propionic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 150082-92-1 tert-Butoxycarbonylamino-acetic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5- fluoro-2'-deoxyuridine derivatives

In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.