752181-34-3

Upstream product

• 107-97-1 sarcosine 
• 150082-92-1 tert-Butoxycarbonylamino-acetic acid 3-[(2R,4S,5R)-4-(4-chloro-benzyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-fluoro-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 
• 50-91-9 5-Fluoro-2'-deoxyuridine 
• 150109-58-3 1-[(2R,4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(4-chloro-benzyloxy)-tetrahydro-furan-2-yl]-5-fluoro-1H-pyrimidine-2,4-dione 
• 103766-46-7 3'-O-(p-chlorobenzyl)-2'-deoxy-5-fluorouridine 
• 129816-30-4 5'-O-(tert-butyldimethylsilyl)-2'-deoxy-5-fluorouridine 
• 34573-36-9 N-[(1,1-dimethylethoxy)carbonyl]glycine chloromethyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of O-alkyl-3-N-aminoacyloxymethyl-5- fluoro-2'-deoxyuridine derivatives

In an attempt to improve the effectiveness of action of 5-fluoro-2'- deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O- p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.