150132-93-7

Upstream product

• 72430-92-3 4-[(3,4-dimethoxyphenyl)methyl]dihydrofuran-2-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 78647-52-6 (+/-)-4-(3,4-dimethoxyphenyl)-3-methoxycarbonylbutanoic acid 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 166884-72-6 1-(1-(allyloxy)-2-iodoethoxy)butane 
• 78173-81-6 <(dimethoxy-3,4 phenyl)hydroxymethyl>-2 (dimethoxy-3,4 benzyl)-3 butanolide-4 
• 108102-79-0 (R)-(+)-α-(dimethoxy-3,4 benzyl)hemisuccinate de methyle 
• 108102-77-8 (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one 
• 149143-88-4 (1S,2S,3S)-1-(3,4-Dimethoxy-phenyl)-3-hydroxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 2898-57-9 1-bromo-2-(3,4-dimethoxybenzyl)-4,5-dimethoxybenzene 
• 2859-78-1 4-Bromoveratrole 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 149143-86-2 3-carbomethoxy-6,7-dimethoxy-1-(1,2-cis)-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-(2,3-cis)-2-carboxylic acid 
• 149143-85-1 (1S,2S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-1,2-dihydro-naphthalene-2,3-dicarboxylic acid 3-methyl ester 

Downstream Products

• 61248-24-6 r-1-(3,4-dimethoxyphenyl)-t-2,c-3-bis(hydroxymethyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene 
• 21966-92-7 isolariciresinol dimethyl ether 

Relevant academic research and scientific papers

Ni-Catalyzed Regioselective Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling and Application to the Concise Synthesis of Lignan Natural Products

We disclose a (terpy)NiBr2-catalyzed reaction protocol that regioselectively difunctionalizes unactivated olefins with tethered alkyl halides and arylzinc reagents. The reaction shows an excellent functional group tolerance (such as ketones, es

A General Asymmetric Synthesis of (-)-α-Dimethylretrodendrin and Its Diastereomers

A Diels-Alder cycloaddition between the fumarate of methyl (R)-mandelate 14 and α-hydroxy-α'-aryl-o-quinodimethane 12 produced an exo cycloadduct 15 in 44percent yield which was converted to optically pure (-)-α-dimethylretrodendrin (21) and three of its

A Common Synthetic Route to the Pericarbonyl and Perimethylene Lignan Lactones Dimethyl Conidendrin and Dimethyl Retrodendrin

An all trans 1-aryl-2-methoxycarbonyl tetralin-3-carboxylic acid synthesised in 32percent overall yield can be converted, at will, to either dimethyl conidendrin or dimethyl retrodendrin in one step.

LIGNANES.10. PREPARATION DES (R)-(+) ET (S)-(-)-β-PIPERONYL ET β-VERATRYL-γ-BUTYROLACTONES ET LEUR UTILISATION DANS LA SYNTHESE TOTALE DE LIGNANES OPTIQUEMENT ACTIFS

A simple and efficient route leading to optically active β-benzyl-γ-butyrolactones is described.Thus, the methyl (R,S)-α-benzylhemisuccinate resulting from a Stobbe condensation with an appropriate aromatic aldehyde, followed by catalytic hydrogenation of the intermediate α-benzylidene hemisuccinic ester, was resolved by means of a chiral base (ephedrine or α-methyl benzylamine).Reduction of each enantiomer, using calcium borohydride, then led to the corresponding optically active β-benzyl-γ-butyrolactone.In this way, the following two lactones were obtained in both (R)-(+) and (S)-(-) enantiomeric forms, β-piperonyl- and β-veratryl-γ-butyrolactones 1 and 2 respectively.These lactones were used as key-intermediates for the syntheses of 17 optically active lignans and lignoids, such as (-)-dimethylmatairesinol (-)-23, (-)-kusunokinin (-)-26 and (+)-dimethylisolariciresinol (+)-35.

Synthesis of Aryltetralin and Dibenzylbutyrolactone Lignans: (+/-)-Lintetralin, (+/-)-Phyltetralin, and (+/-)-Kusunokinin

Application of a general synthetic pathway for aryltetralin and dibenzylbutyrolactone lignans, starting from the lithium enolate of 3-(3,4-dimethoxybenzyl)butyrolactone (1) led to syntheses of (+/-)-lintetralin (4), (+/-)-phyltetralin (5), (+/-)-isogalcat

STRUCTURE AND SYNTHESYS OF HYPOPHYLLANTHIN, NIRTETRALIN, PHYLTETRALIN AND LINTETRALIN

Structures propounded for the four aryltetralin lignan constituents isolated from Phyllanthus niruri Linn. are confirmed by syntheses of their (+/-)-forms.