15017-28-4

Upstream product

• 553-53-7 Nicotinic acid hydrazide 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 59-67-6 nicotinic acid 

Downstream Products

• 1146216-47-8 1-(carboxy(ethoxycarbonyl)methyl)-3-[(2-hydroxybenzylidene)hydrazinocarbonyl]pyridinium bromide 
• 84070-89-3 (C₆H₅)SnCl₃(C₅H₄NCONHNCHC₆H₄OH) 

Relevant academic research and scientific papers

Copper(II) complexes of aroylhydrazones: Preparation and structural characterization

Structures of solid copper complexes with aroylhydrazones obtained from nicotinic acid hydrazide and salicylaldehyde derivatives differing in substituents on the benzene ring were analysed by means of infrared (IR) and Raman spectroscopy. Studied aromatic

Structural and spectroscopic characteristics of aroylhydrazones derived from nicotinic acid hydrazide

Aroylhydrazones derived from salicylaldehyde, o-vanillin and nicotinic acid hydrazide have been synthesized and characterized on the basis of NMR, IR and UV/Vis spectral data. The crystal and molecular structure of N′-salicylidene-3-pyridine-carbohydrazid

Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+/NADH ratios

Background and Purpose: Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional nicot

Tin(IV) complexes with 2-hydroxybenz(2-hydroxynaphth)aldehyde nicotinoylhydrazones (H2Ns, H2Nnf). Molecular and crystal structures of [SnCl3(HNnf)] · 2DMF

The reaction of SnCl4 with 2-hydroxybenz(2-hydroxynaphth)aldehyde nicotinoylhydrazones (H2Ns, H2Nnf) in CH3OH gave non-electrolyte complexes [SnCl3(HNs)] (I) and [SnCl3(HNnf)] (II), which w

Synthesis, structural characterization, in vitro cytotoxicities, and BSA interaction of di-organotin(IV) complexes derived from salicylaldehyde nicotinoyl hydrazone

Two organotin(IV) compounds were synthesized from salicylaldehyde nicotinoyl hydrazone and the corresponding dialkyltin(IV) precursor. Their structures were determined by IR, elemental analysis, NMR, and single crystal X-ray diffraction analysis. Compound

Comparative studies on conventional and solvent-free synthesis toward hydrazones: Application of PXRD and chemometric data analysis in mechanochemical reaction monitoring

Synthesis of hydrazones was performed via both conventional and solvent-free routes using the corresponding hydrazide (isonicotinic hydrazide, nicotinic hydrazide, 2-aminobenzhydrazide or 4-aminobenzhydrazide) and appropriate aldehyde (salicylaldehyde, 3-

Acid–Base Properties and Kinetics of Hydrolysis of Aroylhydrazones Derived from Nicotinic Acid Hydrazide

A series of aroylhydrazones were synthesized from nicotinic acid hydrazide and differently substituted benzaldehydes. The protonation constants of the 12 resulting hydrazones, as well as of the starting compounds, were determined in methanol/water 1/1 mix

Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs

Abstract Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ability to inhibit fungal growth of both azole-susceptible and azole-resistant species of Candida. While many of these analogs showed excellent growth inhibition with low mammalian cell toxicity, their activity did not extend to azole-resistant species of Candida. To further dissect the structural features necessary to inhibit azole-resistant fungal species, we synthesized a new class of modified salicylaldehyde derivatives and subsequently identified a series of modified pyridine-based hydrazones that had potent fungicidal antifungal activity against multiple Candida spp. Here we would like to present our synthetic procedures as well as the results from fungal growth inhibition assays, mammalian cell toxicity assays, time-kill assays and synergy studies of these novel pyridine-based hydrazones on both azole-susceptible and azole-resistant fungal species.

Synthesis, antimycobacterial, antiviral, antimicrobial activities, and QSAR studies of nicotinic acid benzylidene hydrazide derivatives

A series of nicotinic acid benzylidene hydrazide derivatives (1-18) was synthesized and tested in vitro for biological evaluations. The antimycobacterial activity results indicated that the presence of electron-withdrawing halogen groups at para position of the phenyl ring improved their activity. The results of antiviral evaluation depicted that none of the synthesized derivatives inhibited the replication of viruses at subtoxic concentration. Further, the antimicrobial screening results indicated that compounds having OCH3 and NO2 substituents were the most active ones. QSAR investigations revealed that multitarget QSAR models were effective in describing the antimicrobial activity. Springer Science+Business Media, LLC 2011.

1-Malonyl-1,4-dihydropyridine as a novel carrier for specific delivery of drugs to the brain

A group of 1-malonyl-1,4-dihydropyridine derivatives were synthesized as novel carrier systems for site-specific and sustained drug delivery to the brain. Such carriers are expected to be stable against air oxidation due to the presence of the carbonyl group close to nitrogen of the dihydropyridine. These carrier systems were attached to a group of different aldehydes to afford novel quaternary pyridinium derivatives 9a-e, 11a-d, 13 and 18a-b. Reduction of the prepared quaternary pyridinium derivatives with sodium dithionite afforded a novel group of 1-malonyl-1,4-dihydropyridine chemical delivery systems (CDSs) 10a-e, 12a-d, 14 and 19a-b. The synthesized 1-malonyl-1,4-dihydropyridine CDSs were subjected to various chemical and biological investigations to evaluate their ability to cross the blood-brain barrier, and to be oxidized biologically into their corresponding quaternary derivatives. The in vitro oxidation studies showed that most of the 1-malonyl-1,4-dihydropyridine CDSs could be oxidized into their corresponding quaternary derivatives at an adequate rate. The in vivo studies showed that compounds 10c and 14 were able to cross the blood-brain barrier at detectable concentrations. Moreover, the pyridinium quaternary intermediates 9a, 9c, 13, 18a and their corresponding dihydro derivatives 10a, 10c, 14 and 19a were screened for their antidepressant activity using tail suspension behavioral despair test compared to imipramine as a reference at a dose level of 10 mg/kg. The results indicated that compounds 13, 14 and 19a induced remarkable antidepressant activity comparable to imipramine. Compounds 10a, 10c and 18a exhibited good antidepressant activity, their activities nearly equal to 92.8%, 86.7% and 90.20% of the activity of imipramine, respectively. The other derivatives 9a and 9c exhibited moderate antidepressant activity compared with imipramine.