15017-29-5Relevant articles and documents
A Highly Selective and Sensitive Chemosensor for Colorimetric and Fluorescent Detection of Al3+ and Living Cell Imaging
Li, Xiao-Bo,Chen, Jia-Yi,Wang, En-Ju
, p. 156 - 160 (2015)
A colorimetric and fluorescent dual chemosensor for detecting Al3+, (E)-N′-((2-hydroxynaphthalen-1-yl)methylene)nicotinohydrazide (HNN), was developed by combining 2-hydroxy-1-naphthaldehyde with nicotinohydrazide. Addition of Al3+ to EtOH-H2O solution of HNN gives rise to a visible colour change from colourless to light blue and a significantly enhanced fluorescence. Other metal ions including Na+, K+, Ca2+, Mg2+, Mn2+, Co2+, Ni2+, Cu2+, Cr3+, Ag+, Pb2+, Zn2+, Cd2+, Hg2+, Fe2+, and Fe3+ have no or little effect on the specific response of HNN to Al3+. The binding mode of HNN-Al3+ complex was further clarified by electrospray ionisation mass spectrometry and 1H NMR titration experiments.
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD+/NADH ratios
Braidy, Nady,Egan, Suhelen,Huang, Michael L. H.,Palanimuthu, Duraippandi,Richardson, Des R.,Salikin, Nor Hawani,Wu, Zhixuan
, (2020/02/20)
Background and Purpose: Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional nicot
METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE
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Paragraph 00175, (2017/07/05)
A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth.
