150180-17-9

Upstream product

• 50-00-0 formaldehyd 
• 56613-80-0 D-2-phenylglycinol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 130115-53-6 (5R)-4-methyl-5-phenylmorpholin-2-one 
• 150283-97-9 (1S,3aS,6aR)-2-((R)-2-Hydroxy-1-phenyl-ethyl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester 
• 150180-21-5 (1R,3aR,6aS)-2-((R)-2-Hydroxy-1-phenyl-ethyl)-4,6-dioxo-5-phenyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of morpholin-2-ones by chemoselective intramolecular rhodium-catalyzed reductive ring expansion of oxazolidines

(Chemical Equation Presented) The rhodium-catalyzed reductive intramolecular ring expansion of N-(ethoxycarboxymethyl)oxazolidines was carried out under an atmosphere of carbon monoxide and hydrogen to afford N-methylmorpholin-2-ones in good to excellent

Regio- and stereoselective reduction of bicyclic imides for the asymmetric synthesis of highly substituted pyrrolidines

1,3-dipolar cycloaddition of N-phenylmaleimide with azomethine ylides generated from α-aminonitrile or α-aminoester oxazolidines gave bicyclic imides, which were reduced regio- and stereoselectively to hydroxylactams. In the aminonitrile series, reduction with NaBH4/CeCl3 at low temperature gave a single hydroxylactam in high yield. In the aminoester series the regioselectivity was more dependent on the structure, and other conditions (LiBEt3H) were found to obtain a single hydroxylactam which corresponds to a reverse regiochemistry when compared with the aminonitrile series.