1501948-57-7Relevant academic research and scientific papers
Total synthesis of selaginpulvilins A and C
Chinta, Bhavani Shankar,Baire, Beeraiah
, p. 262 - 265 (2018)
An efficient formal total synthesis of two compounds from the selaginpulvilin family of natural products, selaginpulvilin A and C, has been successfully achieved. The tetradehydro Diels-Alder (TDDA) reaction between an enyne and alkyne has been utilized for the creation of the necessary fluorene skeleton. Attempts at the conversion of selaginpulvilin A to selaginpulvilin B, F and H were unsuccessful.
Selaginpulvilins A-D, new phosphodiesterase-4 inhibitors with an unprecedented skeleton from selaginella pulvinata
Liu, Xin,Luo, Hai-Bin,Huang, Yi-You,Bao, Jing-Mei,Tang, Gui-Hua,Chen, Yun-Yun,Wang, Jun,Yin, Sheng
supporting information, p. 282 - 285 (2014/01/23)
Selaginpulvilins A-D (1-4), four new phenols with an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton, together with four known selaginellins (5-8) were isolated from Selaginella pulvinata. Their structures were elucidated by spectroscopic analysis and chemical correlation. The structure of 1 was confirmed by single-crystal X-ray diffraction. Compounds 1-8 exhibited remarkable inhibitory activities (IC50 values in the range of 0.11-5.13 μM) against phosphodiesterase-4 (PDE4), a drug target for the treatment of asthma and chronic obstructive pulmonary disease.
