1501971-56-7

Upstream product

• 1501971-70-5 (R,2E,4E)-6-((tert-butyldimethylsilyloxy)methyl)octa-2,4-dien-1-ol 
• 1501971-69-2 (R,2E,4E)-ethyl 6-(((tert-butyldimethylsilyl)oxy)methyl)octa-2,4-dienoate 
• 1501971-68-1 (2E,4R)-4-(tert-butyldimethylsilyloxymethyl)hex-2-enal 
• 1501971-67-0 (2E,4R)-4-(tert-butyldimethylsilyloxymethyl)-2-hexen-1-ol 
• 122937-66-0 ethyl (2E,4R)-4-(tert-butyldimethylsilyloxymethyl)-2-hexenoate 
• 131815-05-9 (2R)-2-(tert-butyldimethylsilyloxymethyl)butyraldehyde 
• 1501971-50-1 1-(2,4-bis(methoxymethoxy)pyridin-3-yl)ethanol 
• 1501971-48-7 2,4-bis(methoxymethoxy)pyridine 
• 626-03-9 4-hydroxy-2-pyridone 
• 1501971-55-6 (R,2E,4E)-6-((tert-butyldimethylsilyloxy)methyl)octa-2,4-dienal 

Downstream Products

• 1258948-58-1 torrubiellone B 

Relevant academic research and scientific papers

Directed orthometalation and the asymmetric total synthesis of N -deoxymilitarinone A and torrubiellone B

A diverted total synthesis (DTS) approach to the total synthesis of pyridone alkaloids N-deoxymilitarinone A (8) and torrubiellone B (10) has been developed. The common intermediate 14 was first assembled by a dual directed orthometalation process using a methoxymethyl group as directed metalation group. Other crucial steps include the assembly of polyenes under aldol condensation for DTS using general and concise strategy and diastereoselective synthesis of the syn-dimethyl array by an Evans aldol reaction.