150223-76-0

Upstream product

• 1452-63-7 picolinic acid hydrazide 
• 100-70-9 2-Cyanopyridine 
• 100-44-7 benzyl chloride 
• 1671-85-8 3,5-di(pyridin-2-yl)-1,2,4-triazole 

Downstream Products

• 150223-77-1 2,2'-(1-benzyl-1H-1,2,4-triazole-3,5-diyl)bis(pirydine) 

Relevant academic research and scientific papers

Development of luminescent terbium(III) chelates for protein labelling: Effect of triplet-state energy level

The synthesis of novel Tb(III) labels suitable for protein labelling are reported. Their luminescence properties as antibody conjugates were measured and compared to the results of corresponding Tb(III) chelates of the parent ligand structures. When the lowest triplet-state energy level of the parent donor ligand was over 23000 cm-1, i.e., the energy gap between the 5D4 level of Tb(III) and the lowest triplet-state energy level of the ligand exceeded 2600 cm-1, the label derivative with a long decay time (τ = 1.35-2.93 ms) and a high luminescence yield (ε · Φ = 3770-4560) was found to be suitable for bioaffinity assays.

Luminescent lanthanide chelates

Lanthanide chelates which contain three heterocyclic rings covalently coupled to each other (either one 2,6-pyridylene and two five-membered unsaturated heterocyclic ring moieties or two 2,6-pyridylene and one five-membered unsaturated heterocyclic ring moiety) and two chelating groups so seated that they together chelate the same lanthanide ion even in aqueous solutions. These lanthanide chelates can optionally contain a reactive group for coupling to biologically active molecules. The new chelates are suitable for classical lanthanide chelate applications and are also useful as probes in time-resolved fluorescence microscopy, cytometry, multilabelling techniques and in process controls in industry.