1671-85-8

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 318, 1965 DOI: 10.1021/jo01012a522

Upstream product

• 100-70-9 2-Cyanopyridine 
• 1452-63-7 picolinic acid hydrazide 
• 19547-38-7 methyl pyridine-2-imidate 
• 1671-88-1 4-amino-3,5-di-2-pyridyl-4H-1,2,4-triazole 
• 1671-86-9 3,6-di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine 
• 929006-45-1 (3,5-bis(2-pyridyl)-4H-1,2,4-triazolato)copper(I) 

Downstream Products

• 1361953-32-3 C₃₀H₂₀N₆ 
• 1361953-33-4 C₃₀H₂₀N₆ 
• 150223-76-0 1-benzyl-3,5-di(2'-pyridyl)-1,2,4-triazole 

Relevant academic research and scientific papers

Synthesis of some 1,3-disubstituted imidazo[1,5-a]pyridines using 2-cyanopyridine

Heating 2-cyanopyridine and hydrazine hydrate at 100 °C and reheating the resultant liquid with pyridine-2-carboxaldehyde yielded a red semi-solid. On adding aqueous KOH, a mixture of 1-(3,5-bis(2-pyridyl)-1,2,4-triazolyl)-3-(2- pyridyl)imidazo[1,5-a]pyridine (2a) and 1-((2-pyridyl)methanimine)-3-(2-pyridyl) imidazo[1,5-a]pyridine (2b) precipitated and from the filtrate 3,5-bis(2-pyridyl)-1,2,4-triazole (1) was isolated. Similar compounds were obtained from two other pyridinecarboxaldehydes.

Copper-induced N-N bond cleavage results in an octanuclear expanded-core grid-like complex

Reaction of copper(i) acetate and 4-amino-3,5-di(2-pyridyl)-1,2,4-triazole (adpt) in methanol under ambient conditions yields octanuclear [Cu II8(dpt)4(OH)4(OAc)8]; OAc = acetate anion, and dpt- = anion of deaminated adpt, 3,5-di(2-pyridyl)-1,2,4-triazolate. However, reaction of copper(ii) acetate with dptH gives tetranuclear [CuII4(dpt)2(OH)(OMe) (OAc)4]. The Royal Society of Chemistry 2012.

High phenoxazinone synthase activity of two mononuclear: Cis -dichloro cobalt(ii) complexes with a rigid pyridyl scaffold

Phenoxazinone synthase (PHS) is a pentanuclear copper enzyme studied for the last two decades, and though both manganese and copper complexes have been explored extensively, there are only a handful of reports on cobalt mononuclear moieties. In this regard, we have successfully synthesized two cis dichloro cobalt(ii) mononuclear complexes Co(bpy)2Cl2:[1] and Co(L1)2Cl2:[2] with polypyridyl ligands (where bpy = 2,2′-bipyridine, L1 = 2,2′-(1-methyl-1H-1,2,4-triazole-3,5-diyl)dipyridine) and thoroughly characterized them by different spectroscopic and analytical techniques such as FT-IR, 1H NMR, UV-vis spectroscopy and ESI mass spectra. The molecular structures of [1] and [2] are elucidated by single-crystal X-ray diffraction studies. Spectral properties and redox behaviour for both the complexes are examined. The complexes show phenoxazinone synthase activity under ambient conditions and thorough examination of the acquired spectroscopic data imply excellent reactivity for both. Kinetic parameters for both the complexes are evaluated and the turnover numbers (kcat value) of these two complexes are 201.24 h-1 and 249.57 h-1 for [1] and [2], respectively, which are quite high compared to those of previously reported similar complexes. The possible mechanistic route is also established with the help of mass spectroscopy and titrimetric analysis is performed to detect hydrogen peroxide that is a key intermediate formed in the catalysis and thus to prove the involvement of molecular oxygen in the oxidation. This report offers an in-depth summary of metal ion involvement and the extent of the phenoxazinone synthase activity. This journal is

Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes

We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure level

One-pot method for synthetizing 3,5-disubstituted-1,2,4-triazole compounds

The invention provides a one-pot method for preparing 3,5-disubstituted-1,2,4-triazole compounds shown in the general formula (I). In the general formula, at least one of X1, X2, X3 and X4 is selected from a nitrogen atom, and the others are selected from -CH; at least one of X5, X6, X7 and X8 is selected from a nitrogen atom, and the others are selected from -CH. A cascade reaction is adopted, all intermediate products are not separated or purified, that is, aromatic nitrile serving as a raw material has an addition reaction with methoxyl negative ions, and target compounds are synthetized directly under a solvothermal condition. Synthesis steps are simple, after-treatment is convenient, and large-scale production is easy to realize.

Efficient in situ synthesis of 3,5-disubstituted-1,2,4-triazoles under microwave-assisted conditions

Abstract Based on an efficient in situ metal/ligand reaction, a serial of 3,5-disubstituted-1, 2,4-triazoles were synthesized via cycloaddition of organonitriles and ammonia under microwave conditions. This synthetic protocol provides a concise and high-yield access to 3,5-disubstituted-1,2,4-triazoles in organic synthesis. Moreover, the tautomerism of the product was also investigated. Taylor & Francis Group, LLC.

An improved procedure for the deamination of symmetrical 3,5-disubstituted 4-amino-1,2,4-triazoles

A number of symmetrical 3,5-disubstituted-4H-1,2,4-triazoles have been synthesized in good yields by deamination of the corresponding 4-amino-1,2,4-triazoles via reductive diazotation of these amino compounds in the presence of hypophosphorous acid. Analy

Development of luminescent terbium(III) chelates for protein labelling: Effect of triplet-state energy level

The synthesis of novel Tb(III) labels suitable for protein labelling are reported. Their luminescence properties as antibody conjugates were measured and compared to the results of corresponding Tb(III) chelates of the parent ligand structures. When the lowest triplet-state energy level of the parent donor ligand was over 23000 cm-1, i.e., the energy gap between the 5D4 level of Tb(III) and the lowest triplet-state energy level of the ligand exceeded 2600 cm-1, the label derivative with a long decay time (τ = 1.35-2.93 ms) and a high luminescence yield (ε · Φ = 3770-4560) was found to be suitable for bioaffinity assays.

Anti-hyperuricemia composition

Compositions useful in the treatment of gout and hyperuricemia and containing a substituted 1,2,4-triazole as the active ingredient are provided, the triazoles being substituted at the 5 position with a pyridyl radical and at the 3 position with a phenyl