1671-85-8

Basic information

• Product Name: 2-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyridine
• Synonyms: 2-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyridine;2-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)pyridine
• CAS NO: 1671-85-8
• Molecular Formula: C₁₂H₉N₅
• Molecular Weight: 223.23336
• EINECS: -0
• Mol File: 1671-85-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 217-218 °C
• Boiling Point: 505.3°Cat760mmHg
• Flash Point: 245.2°C
• Appearance: /
• Density: 1.303g/cm³
• PKA: 7.54±0.19(Predicted)
• CAS DataBase Reference: 2-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyridine(1671-85-8)
• EPA Substance Registry System: 2-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyridine(1671-85-8)

Safety Data

• Hazardous Substances Data: 1671-85-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 318, 1965 DOI: 10.1021/jo01012a522

Upstream product

• 1671-86-9 3,6-di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine 
• 1671-88-1 4-amino-3,5-di-2-pyridyl-4H-1,2,4-triazole 
• 100-70-9 2-Cyanopyridine 
• 929006-45-1 (3,5-bis(2-pyridyl)-4H-1,2,4-triazolato)copper(I) 
• 1452-63-7 picolinic acid hydrazide 
• 19547-38-7 methyl pyridine-2-imidate 

Downstream Products

• 150223-76-0 1-benzyl-3,5-di(2'-pyridyl)-1,2,4-triazole 
• 1361953-32-3 C₃₀H₂₀N₆ 
• 1361953-33-4 C₃₀H₂₀N₆ 

Relevant articles and documents

Synthesis of some 1,3-disubstituted imidazo[1,5-a]pyridines using 2-cyanopyridine

Heating 2-cyanopyridine and hydrazine hydrate at 100 °C and reheating the resultant liquid with pyridine-2-carboxaldehyde yielded a red semi-solid. On adding aqueous KOH, a mixture of 1-(3,5-bis(2-pyridyl)-1,2,4-triazolyl)-3-(2- pyridyl)imidazo[1,5-a]pyridine (2a) and 1-((2-pyridyl)methanimine)-3-(2-pyridyl) imidazo[1,5-a]pyridine (2b) precipitated and from the filtrate 3,5-bis(2-pyridyl)-1,2,4-triazole (1) was isolated. Similar compounds were obtained from two other pyridinecarboxaldehydes.

Copper-induced N-N bond cleavage results in an octanuclear expanded-core grid-like complex

Reaction of copper(i) acetate and 4-amino-3,5-di(2-pyridyl)-1,2,4-triazole (adpt) in methanol under ambient conditions yields octanuclear [Cu II8(dpt)4(OH)4(OAc)8]; OAc = acetate anion, and dpt- = anion of deaminated adpt, 3,5-di(2-pyridyl)-1,2,4-triazolate. However, reaction of copper(ii) acetate with dptH gives tetranuclear [CuII4(dpt)2(OH)(OMe) (OAc)4]. The Royal Society of Chemistry 2012.

Multimodal Probes: Superresolution and Transmission Electron Microscopy Imaging of Mitochondria, and Oxygen Mapping of Cells, Using Small-Molecule Ir(III) Luminescent Complexes

We describe an Ir(III)-based small-molecule, multimodal probe for use in both light and electron microscopy. The direct correlation of data between light- and electron-microscopy-based imaging to investigate cellular processes at the ultrastructure level

Efficient in situ synthesis of 3,5-disubstituted-1,2,4-triazoles under microwave-assisted conditions

Abstract Based on an efficient in situ metal/ligand reaction, a serial of 3,5-disubstituted-1, 2,4-triazoles were synthesized via cycloaddition of organonitriles and ammonia under microwave conditions. This synthetic protocol provides a concise and high-yield access to 3,5-disubstituted-1,2,4-triazoles in organic synthesis. Moreover, the tautomerism of the product was also investigated. Taylor & Francis Group, LLC.