150254-60-7Relevant academic research and scientific papers
Gold-catalyzed oxidative acyloxylation of arenes
Pradal, Alexandre,Toullec, Patrick Y.,Michelet, Veronique
supporting information; experimental part, p. 6086 - 6089 (2011/12/22)
A variety of nonactivated hindered aromatic rings are acyloxylated (22 examples, up to 83% yield) in the presence of PPh3AuCl as the catalyst and di(acetoxy)iodobenzene as the oxidant. The reaction proceeds at 110 °C in an acid media and allows the formation of both hindered acetoxy and acyloxy derivatives. This methodology nicely complements the Pd-catalyzed arene acyloxylation reaction, which is not operating on hindered substrates and allows the Au-catalyzed unprecedented acyloxylation reaction of arenes, implying various carboxylic acids.
