150258-60-9

Basic information

• Product Name: 5-FORMYL-2-(PHENYLMETHOXY)-BENZOIC ACID PHENYLMETHYL ESTER
• Synonyms: 5-FORMYL-2-(PHENYLMETHOXY)-BENZOIC ACID PHENYLMETHYL ESTER;2-(Benzyloxy)-5-forMylbenzoic Acid Benzyl Ester
• CAS NO: 150258-60-9
• Molecular Formula: C₂₂H₁₈O₄
• Molecular Weight: 346.38
• Product Categories: Aromatics
• Mol File: 150258-60-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 82-83°C
• Boiling Point: 533.1°Cat760mmHg
• Flash Point: 234.2°C
• Appearance: /
• Density: 1.217g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 5-FORMYL-2-(PHENYLMETHOXY)-BENZOIC ACID PHENYLMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FORMYL-2-(PHENYLMETHOXY)-BENZOIC ACID PHENYLMETHYL ESTER(150258-60-9)
• EPA Substance Registry System: 5-FORMYL-2-(PHENYLMETHOXY)-BENZOIC ACID PHENYLMETHYL ESTER(150258-60-9)

Safety Data

• Hazardous Substances Data: 150258-60-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C22H18O4/c23-14-19-11-12-21(25-15-17-7-3-1-4-8-17)20(13-19)22(24)26-16-18-9-5-2-6-10-18/h1-14H,15-16H2

Upstream product

• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 1237514-67-8 2-(2-hydroxy-5-(oxazol-5-yl)benzamido)-4-phenylbenzoic acid 
• 1237519-10-6 tert-butyl 2-(2-(benzyloxy)-5-(oxazol-5-yl)benzamido)-4-phenylbenzoate 
• 1237517-99-5 2-(benzyloxy)-5-(oxazol-5-yl)benzoic acid 
• 1237517-98-4 methyl 2-(benzyloxy)-5-(oxazol-5-yl)benzoate 
• 1285514-89-7 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid 
• 1285514-88-6 ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate 
• 1285514-87-5 methyl ({4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}methyl)carbamate 
• 1285514-59-1 5-[(dimethylamino)methyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide 
• 1285514-57-9 2-[(phenylmethyl)oxy]-N-3-pyridinyl-5-(1-pyrrolidinylmethyl)benzamide 
• 1285514-55-7 5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide 
• 1285514-52-4 ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate 
• 1285514-51-3 5-[(E/Z)-(hydroxylmino)methyl]-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide 
• 1285514-50-2 5-formyl-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide 
• 1285517-19-2 ethyl 3-{4-hydroxy-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.

Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides

Two series of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamide derivatives were designed and synthesized for the evaluation as selective cyclooxygenase-2 (COX-2) inhibitors in a cellular assay using human whole blood (HWB). Extensive structure-activity relationships (SAR) were studied within these series. Several compounds were found to be novel and selective COX-2 inhibitors. Among them, the most potent and selective was 4-(3-carboxy-4-hydroxy-benzylideneamino)benzenesulfonamide (20, LA2135), (IC50's for COX-1: 85.13 μM; COX-2: 0.74 μM; SI: 114.5), being more active COX-2 selective than celecoxib.

THERAPEUTIC AGENT FOR CANCER

A medicament for the prevention and/or treatment of cancers and the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1? a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2? unsubstituted thiazol-2-yl group, or 3? unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ―CONH―E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.