150270-08-9 Usage
Uses
Used in Anticancer Applications:
In the pharmaceutical industry, 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL is used as an anticancer agent for its ability to inhibit HSP90, a protein that plays a crucial role in the survival and proliferation of cancer cells. By targeting HSP90, 17-DMAG can induce apoptosis in various tumor cell lines, making it a potential therapeutic option for cancer treatment.
Used in Drug Delivery Systems:
In the biotechnology industry, 17-(DIMETHYLAMINOETHYLAMINO)-17-DEMETHOXYGELDANAMYCIN HCL is used as a component in drug delivery systems to enhance the efficacy and bioavailability of anticancer drugs. Its cell permeable property allows for better penetration and delivery of the compound to cancer cells, potentially improving the therapeutic outcomes of cancer treatments.
Used in Angiogenesis Inhibition:
In the field of cancer research, 17-DMAG is used as an agent for inhibiting angiogenesis, the process by which new blood vessels form in response to the needs of growing tumors. By disrupting this process, 17-DMAG can limit the growth and metastasis of cancer cells, offering a valuable tool in the fight against cancer.
References
1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637
2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813
Check Digit Verification of cas no
The CAS Registry Mumber 150270-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,2,7 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 150270-08:
(8*1)+(7*5)+(6*0)+(5*2)+(4*7)+(3*0)+(2*0)+(1*8)=89
89 % 10 = 9
So 150270-08-9 is a valid CAS Registry Number.
150270-08-9Relevant academic research and scientific papers
GELDANAMYCIN DERIVATIVES AND THE METHOD FOR BIOSYNTHESIS THEREOF
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Page/Page column 21-22; 4/5, (2008/06/13)
The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene ( gel8 )-inactive mutant, the method producing it and geldanamycin derivatives, 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy geldanamycin and 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy- 17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, antiinflammatory and antitumor agents and an immune su ressant.
