150270-08-9 Usage
Description
17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell Permeable.
References
1) Glaze et al. (2005), Preclinical toxicity of geldanamycin analog 17-(dimethylaminoethylamino)-demethoxygeldanamycin (17-DMAG) in rats and dogs; potential clinical relevance; Cancer Chemother. Pharmacol., 56 637
2) Kaur et al. (2004), Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator; Clin. Cancer Res., 10 4813
Check Digit Verification of cas no
The CAS Registry Mumber 150270-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,2,7 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 150270-08:
(8*1)+(7*5)+(6*0)+(5*2)+(4*7)+(3*0)+(2*0)+(1*8)=89
89 % 10 = 9
So 150270-08-9 is a valid CAS Registry Number.
150270-08-9Relevant articles and documents
GELDANAMYCIN DERIVATIVES AND THE METHOD FOR BIOSYNTHESIS THEREOF
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Page/Page column 21-22; 4/5, (2008/06/13)
The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene ( gel8 )-inactive mutant, the method producing it and geldanamycin derivatives, 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy geldanamycin and 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy- 17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, antiinflammatory and antitumor agents and an immune su ressant.
