150283-04-8Relevant academic research and scientific papers
Process for preparation of Caspofungin acetate
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Page/Page column 4-5, (2010/07/08)
A process for making caspofungin acetate comprising the steps of: A. selectively dehydrating pneumocandin Bo to obtain a nitrile;B. reducing the nitrile to primary amine;C. reacting the primary amine with an arylthiol in a suitable solvent to obtain a thi
Synthesis of the antifungal β-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0
Leonard Jr., William R.,Belyk, Kevin M.,Conlon, David A.,Bender, Dean R.,DiMichele, Lisa M.,Liu, Ji,Hughes, David L.
, p. 2335 - 2343 (2007/10/03)
A novel three-step synthesis of the highly functionalized antifungal agent CANCIDAS (caspofungin acetate, 2) is described, starting from the natural product pneumocandin B0 (1). The highlights of the synthesis include a stereoselective formatio
