15033-43-9Relevant academic research and scientific papers
Selective synthesis of 1,4,5-trisubstituted imidazoles from α-imino ketones prepared by N-heterocyclic-carbene-catalyzed aroylation
Takashima, Ryo,Tsunekawa, Kaoru,Shinozaki, Maki,Suzuki, Yumiko
, p. 2261 - 2267 (2018/04/02)
An alternative synthetic route to 1,4,5-trisubstituted imidazoles from α-imino ketone, which can be prepared from imidoyl chlorides and aromatic aldehydes via N-heterocycle carbene-catalyzed aroylation was developed. This methodology consists of simple tr
Metal-free, acid-promoted synthesis of imidazole derivatives via a multicomponent reaction
Chen, Chung-Yu,Hu, Wan-Ping,Yan, Pi-Cheng,Senadi, Gopal Chandru,Wang, Jeh-Jeng
supporting information, p. 6116 - 6119 (2014/01/17)
An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.
Syntheses of imidazoles and pyrroles: Betmic and tosmic as complementary reagents
Katritzky, Alan R.,Cheng, Dai,Musgrave, Richard P.
, p. 67 - 70 (2007/10/03)
p-Tolylsulfonylmethyl isocyanide (TosMIC) and benzotriazol-1-yl-methyl isocyanide (BetMIC) were compared as to their synthetic utilities for the synthesis of imidazoles and pyrroles and found to be complementary.
4,5-DIPHENYLIMIDAZOLES FROM THE CYCLIZATION OF BENZIL N-ALKYLMONOHYDRAZONES
Collibee, William L.,Anselme, Jean-Pierre
, p. 655 - 662 (2007/10/02)
The thermal cyclization of monodisubstituted hydrazones (1) affords the corresponding N-substituted-4,5-diphenylimidazoles in good to excellent yields; possible mechanisms for this unusual cyclization are presented.
THE UNUSUAL CYCLIZATION OF BENZIL MONOHYDRAZONES TO 4,5-DIPHENYLIMIDAZOLES
Collibee, William L.,Anselme, Jean-Pierre
, p. 1595 - 1596 (2007/10/02)
Benzil monodisubstituted hydrazones (2) have been shown to undergo cyclodehydration to the corresponding imidazoles (10) and not to pyrazoles as previously reported.
The Copper-Catalysed Reaction of 2-Chloroimidazoles and 2-Chlorobenzimidazoles with Dimethylamine
Whittle, Chrostopher P.
, p. 1545 - 1551 (2007/10/02)
The preparation of 2-dimethylamino-benzimidazoles and -imidazoles from the corresponding 2-chloro compounds by reaction with dimethylamine is assisted by the presence of copper salts.In the absence of a copper catalyst, 2-chloroimidazoles fail to react.Ki
