150337-73-8

Basic information

• Product Name: Pentanoic acid, 2-hydroxy-4-oxo-, (R)- (9CI)
• Synonyms: Pentanoic acid, 2-hydroxy-4-oxo-, (R)- (9CI)
• CAS NO: 150337-73-8
• Molecular Formula: C₅H₈O₄
• Molecular Weight: 132.11462
• Product Categories: ACETYLGROUP
• Mol File: 150337-73-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pentanoic acid, 2-hydroxy-4-oxo-, (R)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 2-hydroxy-4-oxo-, (R)- (9CI)(150337-73-8)
• EPA Substance Registry System: Pentanoic acid, 2-hydroxy-4-oxo-, (R)- (9CI)(150337-73-8)

Safety Data

• Hazardous Substances Data: 150337-73-8(Hazardous Substances Data)

Upstream product

• 67-64-1 acetone 
• 298-12-4 Glyoxilic acid 

Relevant articles and documents

Glyoxylic acid versus ethyl glyoxylate for the aqueous enantio selective Synthesis of α-hydroxy-γ-keto acids and esters by the N-Tosyl-(S a)-binam-l-prolinamide-organocatalyzed aldol reaction

N-Tosyl-(S a)-binam-l-prolinamide is an efficient catalyst for the aqueous aldol reaction between ketones and glyoxylic acid, as the monohydrate or as an aqueous solution, or a 50% toluene solution of ethyl glyoxylate. These reactions led to the formation of chiral α-hydroxy-γ-keto carboxylic acids and esters in high levels of diastereo- and enantioselectivities (up to 97% ee), providing mainly anti aldol products. Only cyclopentanone and cyclohexane-1,4-dione afforded an almost 1:1 mixture of the syn/anti-diastereoisomers; however, the reaction between 4-phenylcyclohexanone and ethyl glyoxylate gave the corresponding syn,syn-product as the major diastereoisomer.