150356-60-8Relevant articles and documents
An unprecedented asymmetric Nazarov cyclization for the synthesis of nonracemic indanes as endothelin receptor antagonists
Pridgen, Lendon N.,Huang, Kris,Shilcrat, Susan,Tickner-Eldridge, Ann,DeBrosse, Charles,Haltiwanger, R. Curtis
, p. 1612 - 1614 (2007/10/03)
An asymmetric synthesis of the novel nonracemic endothelin receptor antagonists, SB 209670 (1a) and SB 217242 (1b) is described which utilizes an unprecedented asymmetric Nazarovtype ring closure of the alkylidene-1,3- carbonyl compounds. Excellent 1,5-induction is observed which establishes the required S configuration at the C-3 carbon of an indane skeleton.
ENDOTHELIN RECEPTOR ANTAGONISTS
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, (2008/06/13)
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