214271-70-2Relevant academic research and scientific papers
An unprecedented asymmetric Nazarov cyclization for the synthesis of nonracemic indanes as endothelin receptor antagonists
Pridgen, Lendon N.,Huang, Kris,Shilcrat, Susan,Tickner-Eldridge, Ann,DeBrosse, Charles,Haltiwanger, R. Curtis
, p. 1612 - 1614 (1999)
An asymmetric synthesis of the novel nonracemic endothelin receptor antagonists, SB 209670 (1a) and SB 217242 (1b) is described which utilizes an unprecedented asymmetric Nazarovtype ring closure of the alkylidene-1,3- carbonyl compounds. Excellent 1,5-induction is observed which establishes the required S configuration at the C-3 carbon of an indane skeleton.
Endothelin receptor antagonists
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, (2008/06/13)
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
