150360-28-4

Upstream product

• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 2003-14-7 (3-trifluoromethyl-phenyl)-acetyl chloride 
• 145983-07-9 α-methyl-α-(m-trifluoromethylphenyl)malonic acid 
• 138485-29-7 2-[3-(trifluoromethyl)phenyl]malonic acid-1,3-dimethyl ester 
• 62451-84-7 (3-trifluoromethyl-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of cinacalcet impurity (by machine translation)

The invention discloses a preparation method, namely, a cinacalcet impurity. Belong to pharmaceutical synthesis field, whole process design is reasonable, maneuverability is strong, and purification is convenient. To the method, the optimal preparation st

Microbial asymmetric decarboxylation of fluorine-containing arylmalonic acid derivatives

α-Methyl-α-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active α-arylpropionic acids.Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing.Decarboxylation of α-fluoro-α-phenylmalonic acid with the aid of the same bacterium afforded optically active α-fluoro-α-phenylacetic acid.