150408-99-4

Basic information

• Product Name: (1S,2R)-1-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-2-phenyl-cyclopropanecarboxylic acid methyl ester
• CAS NO: 150408-99-4
• Molecular Weight: 569.701
• Mol File: 150408-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,2R)-1-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-2-phenyl-cyclopropanecarboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-1-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-2-phenyl-cyclopropanecarboxylic acid methyl ester(150408-99-4)
• EPA Substance Registry System: (1S,2R)-1-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-2-phenyl-cyclopropanecarboxylic acid methyl ester(150408-99-4)

Safety Data

• Hazardous Substances Data: 150408-99-4(Hazardous Substances Data)

Upstream product

• 130406-40-5 N-[(2-adamantyloxy)-carbonyl]-α-methyl-R-tryptophane 
• 123806-65-5 methyl (1S,2R)-1-amino-2-phenylcyclopropanecarboxylate 
• 150351-77-2 (Z,S)-1-Acetyl-3-benzylidene-6-(1-methylethyl)piperazine-2,5-dione 

Relevant articles and documents

Preparation of dipeptoid mimetics for the tetrapeptide cholecystokinin, CCK(30-33)

The diastereoselective synthesis of 2,3-methanophenylalanine methyl esters (5) has been achieved in 58% yield. The preparation of the dehydropeptides (1, R = Me; 2, R = H) and the cyclopropylpeptides (3, R = Me; 4, R = H) possessing good binding affinities for the CCK-A and CCK-B receptors is described. Conformational studies of the dipeptide esters 1 and 3 indicated the presence of a β-turn within the peptide backbone, although there was no preference in type. The Phe and Trp moieties, however, did prefer to be situated on the same side of the peptide turn which is favourable for receptor binding.