15044-65-2

Basic information

• Product Name: 7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• Synonyms: 7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• CAS NO: 15044-65-2
• Molecular Weight: 328.321
• Mol File: 15044-65-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one(15044-65-2)
• EPA Substance Registry System: 7-hydroxy-5,8-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one(15044-65-2)

Safety Data

• Hazardous Substances Data: 15044-65-2(Hazardous Substances Data)

Upstream product

• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 20032-42-2 2,5-dimethoxyresorcinol 
• 794-94-5 p-Methoxybenzoic anhydride 
• 7499-99-2 1-(2,4-dihydroxy-3,6-dimethoxy)phenylethanone 
• 6274-74-4 2,6-dibenzyloxy-1,4-dimethoxybenzene 
• 42528-81-4 2,6-bis-benzyloxy-benzene-1,4-diol 
• 6625-45-2 2,6-bis-benzyloxy-[1,4]benzoquinone 
• 55020-64-9 1,2,3-tris-benzyloxybenzene 
• 87-66-1 2-hydroxyresorcinol 

Downstream Products

• 529-53-3 scutellarein 
• 6601-66-7 6-demethoxytangeretin 

Relevant articles and documents

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Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

A novel series of 49 wogonin derivatives were synthesized by introducing group at 7-, 8- or B ring of wogonin. The cytotoxic activities against HepG2, A549 and BCG-823 cancer cell lines were also investigated in vitro. Several of them showed obvious cytotoxic activities and compound 3h possessed the highest potency against HepG2, A549, and BCG-823 with IC50 values of 1.07 μM, 1.74 μM and 0.98 μM, respectively. A quantitative structure-activity relationship (QSAR) study of these synthetic derivatives as well as wogonin indicated that high solubility and low octanol/water partition coefficient are favorable, and excessive electrostatic properties and refractivity are unfavorable for the cytotoxic activities of these wogonin derivatives. These findings and results provide a base for further investigations.