150454-06-1 Usage
Description
4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid amide is a chemical compound with the molecular formula C10H10N2O3. It is a derivative of quinazoline and is classified as an amide. 4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid aMide is known for its potential biological and pharmaceutical properties, making it a subject of interest for the development of drugs to treat various medical conditions. Its unique structure and properties also position it as a valuable building block in organic synthesis for creating new compounds with specific properties or functions. 4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid aMide's significance lies in its potential applications across medicine, pharmacology, and organic chemistry, warranting further research and development.
Uses
Used in Pharmaceutical Development:
4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid amide is used as a pharmaceutical precursor for the development of drugs targeting a range of medical conditions. Its unique chemical structure allows it to be a promising candidate in medicinal chemistry for the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, 4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid amide serves as a key building block. It is utilized for the synthesis of new compounds with tailored properties, which can be applied in various chemical and material science applications.
Used in Medicinal Chemistry Research:
4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid aMide is employed as a subject of study in medicinal chemistry to explore its interactions with biological targets. Understanding these interactions can lead to the discovery of new drugs with improved efficacy and safety profiles.
Used in Drug Discovery:
4-Oxo-3,4-dihydro-quinazoline-6-carboxylic acid amide is used in drug discovery processes to identify potential lead compounds. Its unique properties may offer new avenues for treating diseases by modulating specific biological pathways or targets.
Check Digit Verification of cas no
The CAS Registry Mumber 150454-06-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,0,4,5 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 150454-06:
(8*1)+(7*5)+(6*0)+(5*4)+(4*5)+(3*4)+(2*0)+(1*6)=101
101 % 10 = 1
So 150454-06-1 is a valid CAS Registry Number.
150454-06-1Relevant articles and documents
Cyclic GMP Phosphodiesterase Inhibitors. 2. Requirement of 6-Substitution of Quinazoline Derivatives for Potent and Selective Inhibitory Activity
Takase, Yasutaka,Saeki, Takao,Watanabe, Nobuhisa,Adachi, Hideyuki,Souda, Shigeru,Saito, Isao
, p. 2106 - 2111 (1994)
We synthesized various 4-amino>quinazolines substituted at the 5- to 8-positions and evaluated their inhibitory activities toward cyclic GMP phosphodiesterase (cGMP-PDE) from porcine aorta.Monosubstitution at the 6-position was essential for the inhibitory activity, and the preferred substituents were compact and hydrophobic: methoxy (3b, IC50 = 0.23 μM), methyl (3c, 0.10 μM), chloro (3d, 0.019 μM), thiomethyl (3f, 0.031 μM), and cyano (3p, 0.090 μM) groups.Compounds 3b-d, f, p lacked inhibitory activity toward other PDE isozymes (all IC50 values > 100 μM), and their relaxing activities in porcine coronary arteries were well correlated with the inhibitory activities toward cGMP-PDE (r = 0.88, p 0.05).One of these compounds, 3b, elevated the intracellular cGMP level in isolated porcine coronary arteries without causing any change in the cAMP level.We consider that this series of compounds dilates coronary arteries via potent and specific inhibition of cGMP-PDE.
