1504585-16-3

Usage

Class

Triphenylethylene derivatives

Function

Estrogen receptor antagonist

Potential Applications

a. Treatment of hormone-dependent cancers (e.g., breast cancer)
b. Hormone replacement therapy
c. Studying estrogen receptor function

Properties

a. Anti-estrogenic
b. Anti-tumor

Structure

Unique chemical structure with a phenyl group, an ethene group, and an aminomethyl group attached to the phenyl ring

Significance

Promising candidate for cancer therapy and other medical and scientific applications due to its biological properties and chemical structure.

Upstream product

• 125847-08-7 1-(4-methylphenyl)-1,2,2-triphenylethanol 
• 1403677-99-5 (2-(4-(azidomethyl)phenyl)ethene-1,1,2-triyl)tribenzene 
• 1361969-01-8 (2-(4-(bromomethyl)phenyl)ethene-1,1,2-triyl)tribenzene 
• 70592-06-2 1,1,2-triphenyl-2-(p-methylphenyl)ethylene 
• 134-84-9 4-Methylbenzophenone 
• 101-81-5 Diphenylmethane 

Downstream Products

• 1504585-21-0 C₅₅H₆₁N₇O₁₇ 
• 1504585-20-9 C₅₃H₅₇N₇O₁₇S₂ 
• 1504585-18-5 C₈₀H₉₅N₁₅O₂₄S₂ 

Relevant academic research and scientific papers

Aggregation-induced emission or aggregation-caused quenching? Impact of covalent bridge between tetraphenylethene and naphthalimide

Understanding the physical mechanisms governing aggregation-induced-emission (AIE) and aggregation-caused-quenching plays a vital role in developing functional AIE materials. In this work, tetraphenylethene (TPE, a classical AIEgen) and naphthalimide (NI, a popular fluorophore with ACQ characteristics) were connected through non-conjugated linkages and conjugated linkages. We showed that the nonconjugated-linkage of TPE to NI fragments leads to substantial PET in molecular aggregates and ACQ. In contrast, the conjugated connection between TPE and NI moieties results in the AIE phenomenon by suppressing twisted intramolecular charge transfer. This work provides an important guideline for the rational design of AIE materials.

Enzyme-responsive reporter molecules for selective localization and fluorescence imaging of pathogenic biofilms

Pathogenic bacteria and their biofilm formation are responsible for a broad spectrum of microbial infections. A novel enzyme-responsive reporter molecule (ERM-1), which can specifically recognize AmpC β-lactamase (Bla) in drug resistant bacteria, has been developed to enable the selective localization of biofilms.

Rational design of fluorescent light-up probes based on an AIE luminogen for targeted intracellular thiol imaging

A water-soluble fluorescent light-up bioprobe based on a luminogen with aggregation-induced emission characteristics was developed for targeted intracellular thiol imaging.