1504589-20-1Relevant academic research and scientific papers
AZOLE-SUBSTITUTED PYRIDINE COMPOUND
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Paragraph 0663; 0664; 0696, (2019/01/08)
The present invention provides a compound represented by formula [I'| shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme, wherein the structure represented by formula [III] shown below represents any of the structures represented by formula group [IV] shown below, wherein R1 represents a hydrogen atom, a fluorine atom, methyl, etc.; R2, R3, and R4 each independently represent a hydrogen atom, a fluorine atom, or methyl; W represents a single bond, C1-3alkanediyl, or the formula -O-CH2CH2-; and ring A represents (a) substituted C4-6cycloalkyl, (b) substituted 4- to 6-membered saturated nitrogen-containing heterocyclyl, (c) substituted phenyl, (d) substituted pyridyl, (e) substituted 2,3-dihydrobenzofuran, (f) 4- to 6-membered saturated oxygen-containing heterocyclyl, etc.
Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides
Rocke, Benjamin N.,Bahnck, Kevin B.,Herr, Michael,Lavergne, Sophie,Mascitti, Vincent,Perreault, Christian,Polivkova, Jana,Shavnya, Andrei
supporting information, p. 154 - 157 (2014/01/23)
Organozinc reagents react with the SO2 surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones. This transformation has a broad scope and is compatible with a wide range of structural motifs of medicinal
