282727-18-8 Usage
General Description
3-(ethoxycarbonyl)phenylzinc iodide is an organozinc compound that is commonly used in organic synthesis as a reactive reagent for the preparation of various organic compounds. It is a white to off-white solid that is highly reactive towards a wide range of electrophiles, making it a valuable tool for the formation of carbon-carbon and carbon-heteroatom bonds. The ethoxycarbonyl group in the compound provides a source of a carbanion equivalent that can be used in a variety of carbon-carbon bond-forming reactions, while the phenyl and zinc iodide components provide the necessary reactivity and stereospecificity for efficient organic synthesis. Overall, 3-(ethoxycarbonyl)phenylzinc iodide is an important and versatile reagent for the preparation of complex organic molecules in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 282727-18-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,2,7,2 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 282727-18:
(8*2)+(7*8)+(6*2)+(5*7)+(4*2)+(3*7)+(2*1)+(1*8)=158
158 % 10 = 8
So 282727-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H9O2.HI.Zn/c1-2-11-9(10)8-6-4-3-5-7-8;;/h3-4,6-7H,2H2,1H3;1H;/q-1;;+2/p-1/rC9H9O2.IZn/c1-2-11-9(10)8-6-4-3-5-7-8;1-2/h3-4,6-7H,2H2,1H3;/q-1;+1
282727-18-8Relevant articles and documents
Rhodium-Catalyzed Addition of Organozinc Iodides to Carbon-11 Isocyanates
Fouad, Moustafa H.,Ismailani, Uzair S.,Mair, Braeden A.,Munch, Maxime,Rotstein, Benjamin H.
supporting information, p. 2746 - 2750 (2020/04/16)
Amides were prepared using rhodium-catalyzed coupling of organozinc iodides and carbon-11 (11C, t1/2 = 20.4 min) isocyanates. Nonradioactive isocyanates and sp3 or sp2 organozinc iodides generated amides in yields of 13%-87%. Incorporation of cyclotron-produced [11C]CO2 into 11C-amide products proceeded in yields of 5%-99%. The synthetic utility of the methodology was demonstrated through the isolation of [11C]N-(4-fluorophenyl)-4-methoxybenzamide ([11C]6g) with a molar activity of 267 GBq μmol-1 and 12% radiochemical yield in 21 min from the beginning of synthesis.
