150465-58-0Relevant academic research and scientific papers
Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor
Zablocki,Miyano,Garland,Pireh,Schretzman,Rao,Lindmark,Panzer-Knodle,Nicholson,Taite,Salyers,King,Campion,Feigen
, p. 1811 - 1819 (2007/10/02)
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involved in
