15049-50-0Relevant academic research and scientific papers
Simple synthesis of 4-thiothymidine, 4-thiouridine and 6-thio-2′-deoxyguanosine
Xu, Yao-Zhong,Zheng, Qinguo,Swann, Peter F.
, p. 2817 - 2820 (2007/10/02)
4-triazolo-pyrimidine nucleosides and 6-O-(mesitylenesulfonyl)-2′-deoxyguanosine, when treated with thiolacetic acid at room temperature, gave the corresponding 4-thiopyrimidine nucleosides and 6-thio-2′-deoxyguanosine with high yields (86-93%). Possible mechanisms are discussed.
REACTION OF URACIL NUCLEOSIDES WITH 1-METHYLIMIDAZOLE IN THE PRESENCE OF PHOSPHORYL CHLORIDE: A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-SUBSTITUED PYRIMIDIN-2(1H)-ONE NUCLEOSIDES
Matsuda, Akira,Obi, Kikoh,Miyasaka, Tadashi
, p. 2574 - 2578 (2007/10/02)
Reaction of 2',3',5'-tri-O-benzoyluridine (3) with 1-methylimidazole in the presence of phosphoryl chloride in acetonitrile afforded 3-methyl-1-imidazolium intermediate (4), from which a variety of 4-substituted pyrimidin-2(1H)-one ribosides (5-12) were o
