1505-47-1

Basic information

• Product Name: 3-THIOPHENEBUTANOIC ACID
• Synonyms: 3-THIOPHENEBUTANOIC ACID;4-(3-THIENYL)BUTYRIC ACID;4-(thiophen-3-yl)butanoic acid
• CAS NO: 1505-47-1
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.23
• Mol File: 1505-47-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 300.969°C at 760 mmHg
• Flash Point: 135.821°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-THIOPHENEBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-THIOPHENEBUTANOIC ACID(1505-47-1)
• EPA Substance Registry System: 3-THIOPHENEBUTANOIC ACID(1505-47-1)

Safety Data

• Hazardous Substances Data: 1505-47-1(Hazardous Substances Data)

Usage

Uses

3-Thiophenebutyric Acid is used for preparation of cyclic aryl ketones via Friedel Crafts acylation of arylalkyl acid chlorides in hexafluoropropanol.

InChI:InChI=1/C8H10O2S/c9-8(10)3-1-2-7-4-5-11-6-7/h4-6H,1-3H2,(H,9,10)

Upstream product

• 57070-76-5 2-(3'-thiophenyl)-1-bromoethane 
• 498-62-4 3-thiophene carboxaldehyde 
• 19995-16-5 2-(2-(thiophen-3-yl)ethyl)malonic acid 
• 114896-64-9 3-thiopheneethanol methanesulfonate (ester) 
• 19995-15-4 diethyl 2-(2-(thiophen-3-yl)ethyl)malonate 
• 114896-65-0 3-(2'-iodoethyl) thiophene 
• 13781-67-4 3-(2-hydroxyethyl)thiophene 

Downstream Products

• 1468-84-4 5,6-dihydro-4H-benzothiophen-7-one 

Relevant articles and documents

Water-Soluble Conducting Polymers

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Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

The compounds of the present invention are represented by the chemical structure found in Formula (I): wherein: the carbon atom designated * is in the R or S configuration; and X is a fused bicyclic carbocycle or heterocycle selected from the group consisting of benzofuranyl, benzo[b]thiophenyl, benzoisothiazolyl, benzoisoxazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, benzotriazolyl, imidazo[1,2-a]pyridinyl, pyrazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, thieno[2,3-b]pyridinyl, thieno[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzocycloheptenyl, tetrahydrobenzocycloheptenyl, dihydrobenzothiophenyl, dihydrobenzofuranyl, indolinyl, naphthyl, tetrahydronaphthyl, quinolinyl, isoquinolinyl, 4H-quinolizinyl, 9aH-quinolizinyl, quinazolinyl, cinnolinyl, phthalazinyl, quinoxalinyl, benzo[1,2,3]triazinyl, benzo[1,2,4]triazinyl, 2H-chromenyl, 4H-chromenyl, and a fused bicyclic carbocycle or fused bicyclic heterocycle optionally substituted with substituents (1 to 4 in number) as defined in R14; with R1, R2, R3, R4, R5, R6, R7, R8, and R14 defined herein.