57070-76-5Relevant academic research and scientific papers
A new efficient route to 3-vinylthiophene
Nicolas, Mael,Fabre, Bruno,Pilard, Jean-Francois,Simonet, Jacques
, p. 1105 - 1106 (1999)
The synthesis of 3-vinylthiophene was efficiently achieved in two steps. 3-(2-bromoethyl)thiophene prepared from 3-(2- ethanol)thiophene was converted to the title compound (70% overall yield) using tetraglyme as a solvent and 1,8- diazabicyclo[5.4.0]undec-7-ene as a base.
Conjugated polymer network films from precursor polymers: Electrocopolymerization of a binary electroactive monomer composition
Taranekar, Prasad,Baba, Akira,Fulghum, Timothy M.,Advincula, Rigoberto
, p. 3679 - 3687 (2005)
We report the synthesis and electropolymerization of a precursor polymer with a binary molecular composition of thiophene and carbazole electroactive groups to form ultrathin films of conjugated polymer networks (CPN) on flat indium tin oxide (ITO) substrates. In the past we have demonstrated the precursor polymer approach based on a single pendant electroactive group. In this work, we describe the interesting electrocopolymerization mechanism and properties of precursor polymers prepared with two different types of pendant electroactive groups (statistical copolymer) and compared behavior to their respective homopolymers. The presence of a smaller amount of carbazole induces the electropolymerization of the higher oxidation potential thiophene units via the reaction of a radical cation and a neutral molecule pathway. These electrochemically generated thin films gave unique optical, electrochemical, and morphological properties as a function of composition. The film properties were investigated by cyclic voltammetry (CV), spectroelectrochemistry, EQCM, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS).
Catalytic Asymmetric Disulfuration by a Chiral Bulky Three-Component Lewis Acid-Base
Zhang, Qi,Li, Yao,Zhang, Long,Luo, Sanzhong
supporting information, p. 10971 - 10976 (2021/04/09)
A three-component Lewis acid–base (Lewis trio) involving a bulky chiral primary amine, B(C6F5)3 and a bulky tertiary amine has been developed as an effective enamine catalyst for enantioselective disulfuration reactions. The bulky tertiary amine was found to activate a bulky primary–tertiary diamine–borane Lewis pair for enamine catalysis via frustrated interaction. The resulted chiral bulky Lewis trio (BLT) allows for the construction of chiral disulfides via direct disulfuration with β-ketocarbonyls or α-branched aldehydes in a practical and highly stereocontrolled manner.
Thermal and solvatochromic effects on the emission properties of a thienyl-based dansyl derivative
Almeida, A. K. A.,De Abreu, A. C. F.,De Oliveira, I. N.,Dias, J. M. M.,Ito, A. S.,Manzoni, V.,Navarro, M.,Pazin, W. M.,Ribeiro, A. S.
, p. 28484 - 28491 (2020/08/25)
Environmental conditions have a profound effect on the photophysical behavior of highly conjugated compounds, which can be exploited in a large variety of applications. In this context, we use a combination of experimental and computational methods to investigate thermal and solvatochromic effects on the fluorescence properties of a dansyl derivative bearing a thienyl substituent, namely 2-(3-thienyl)ethyl dansylglycinate (TEDG). In particular, we analyze how the solvent polarity and temperature affect the ground and excited state energies of TEDG by using time-resolved and steady-state fluorescence techniques. We determine the changes in dipole moment of the TEDG molecule upon photoexcitation, as well as the solvent polarity effects on the excited state lifetime. Besides, we provide theoretical modeling of the HOMO-LUMO orbitals and the vertical absorption and emission energies using time-dependent density functional theory (TDDFT) as well as the polarizable continuum model (PCM) to include the solvent contribution to the absorption and emission energies. Our results show that the emission mechanism of TEDG involves locally excited states derived from hybrid molecular orbitals, accompanied by a moderate variation of the molecular dipole moment upon light excitation. Our findings demonstrate that TEDG exhibits desirable fluorescence properties that make it a promising candidate for use as a photoactive material in electrochromic, optical thermometry, and thermography applications.
NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF
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Paragraph 00369, (2020/12/01)
The invention provides compounds for inhibiting glucosylceramidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds.
FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS
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Page/Page column 117; 118, (2015/07/16)
The present invention provides fused thiophene and thiazole derivatives of formula (I), which may be therapeutically useful, more particularly as RORγ modulators; in which R1, R2, R3, R4, R5, R6, R7, X1, X2, L, m, n and ring A have the meanings given in the specification, and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in disease(s) or disorder(s) where there is an advantage in modulating RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the fused thiophene and thiazole derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
Small-molecule allosteric activation of human glucokinase in the absence of glucose
Bowler, Joseph M.,Hervert, Katherine L.,Kearley, Mark L.,Miller, Brian G.
supporting information, p. 580 - 584 (2013/07/26)
Synthetic allosteric activators of human glucokinase are receiving considerable attention as potential diabetes therapeutic agents. Although their mechanism of action is not fully understood, structural studies suggest that activator association requires
Synthesis and spectroscopic properties of a novel perylenediimide derivative
Hakli-Birel, Oezguel,Dincalp, Haluk,Zafer, Ceylan,Demic, Serafettin,Colladet, Kristof,Vanderzande, Dirk,Yueruem, Yuda,Icli, Siddik
experimental part, p. 403 - 411 (2012/05/04)
A novel symmetric 3,4,9,10-perylenetetracarboxylic acid derivative (PDI1) dye based on thiophene donor group was synthesized and characterized by FT-IR and 1H NMR. Cyclic Voltammetry analysis is performed to determine the energy levels of the p
TRICYCLIC 2,4-DIAMIN0-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS
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Page/Page column 99-100, (2010/01/07)
The present invention relates to compounds of Formula (I): (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer.
A palladium-catalyzed approach to polycyclic sulfur heterocycles
Martins, Andrew,Lautens, Mark
scheme or table, p. 8705 - 8710 (2009/04/11)
(Chemical Equation Presented) The synthesis of a variety of polycyclic thiophenes and benzothiophenes is accomplished via a palladium-catalyzed domino ortho-alkylation/direct arylation reaction. An examination of the intramolecular direct arylation of thi
