15054-53-2

Usage

Uses

Used in Agricultural Industry:
1-(2-methylpropyl)-3-phenylurea is used as a pre-emergent herbicide for controlling weeds in various crops such as rice, corn, and soybeans. Its application helps prevent weed growth before planting, ensuring a healthy and productive crop yield.
It is important to handle and apply Terbumeton with caution due to its toxic nature, which may pose health risks to humans and the environment if not used properly.

Upstream product

• 62-53-3 aniline 
• 1873-29-6 isobutyl isocyanate 
• 108-12-3 isopentanoyl chloride 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 78-81-9 isobutylamine 
• 25645-81-2 hydrazinecarbothioic acid O-isobutyl ester 
• 1768-25-8 Isobutyl-cyanat 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 
• 37534-82-0 2,2,2-trichloroethyl phenylcarbamate 
• 18992-89-7 allyl N-phenylcarbamate 
• 25449-52-9 5-isobutoxy-[1,2,3,4]thiatriazole 
• 155959-77-6 isobutylcarbamoyl azide 

Downstream Products

• 392691-44-0 1-[4-(4-aminomethyl-piperidine-1-sulfonyl)-phenyl]-3-isobutyl-urea 

Relevant academic research and scientific papers

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

CaI2-Catalyzed direct transformation of: N -Alloc-, N -Troc-, and N -Cbz-protected amines to asymmetrical ureas

A novel and facile CaI2-catalyzed direct synthesis of asymmetrical ureas from N-Alloc-, N-Troc-, and N-Cbz-protected amines is developed. In this study, the efficient reaction of Alloc-, Troc-, and Cbz-carbamates with amines in the presence of catalytic CaI2 successfully generated various asymmetrical ureas. This catalytic synthetic procedure provided the desired ureas via reactions of these protected aromatic and aliphatic amines with various amines in high yields without side products. This suggests that novel direct synthesis of ureas from Alloc-, Troc-, and Cbz-carbamates can be a promising approach for the synthesis of useful ureas.

Facile one-pot synthesis of unsymmetrical ureas, carbamates, and thiocarbamates from Cbz-protected amines

A novel one-pot synthesis of unsymmetrical ureas, carbamates and thiocarbamates from Cbz-protected amines has been developed. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, isocyanates are generated in situ, which facilitate rapid reaction with amines, alcohols, and thiols to afford the corresponding ureas, carbamates and thiocarbamates in high yields.

Novel substituted 4-aminomethylpiperidines as potent and selective human β3-agonists. Part 1: Aryloxypropanolaminomethylpiperidines

The synthesis and SAR of a series of human β3 adrenoreceptor agonists based on a template derived from a common pharmacophore coupled with 4-aminomethylpiperidine is described. Potent and selective agents were identified such as 26 that was in vitro active in CHO cells expressing human β3-AR (EC50=49 nM, IA=1.1), and in vivo active in a transgenic mouse model.