150543-34-3

Usage

Type of compound

Derivative of pyrrolidine

Structural features

Contains a benzyl group and a methylene group

Applications

Building block in the synthesis of pharmaceuticals and agrochemicals

Potential uses

Development of new materials, reagent in organic chemistry reactions

Odor

Characteristic odor

Stability

Stable under normal conditions

Safety precautions

Handle with care, follow proper safety procedures in laboratory settings

Upstream product

• 775-16-6 N-benzyl-3-pyrrolidinone 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Relevant academic research and scientific papers

Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents

Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.

SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS

The present invention relates to substituted spiro compounds, processes for preparing them, medicaments comprising these compounds, and the use of these compounds for producing medicaments.