Chemical and Pharmaceutical Bulletin p. 1971 - 1986 (1993)
Update date:2022-08-04
Topics:
Mimura
Hayashida
Nomiyama
Ikegami
Iida
Tamura
Hiyama
Ohishi
Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.
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Doi:10.1135/cccc19931122
(1993)Doi:10.1021/jo00071a030
(1993)Doi:10.1039/b207721c
(2003)Doi:10.1246/cl.1993.1357
(1993)Doi:10.1021/bc900517x
(2010)Doi:10.1016/S0040-4039(00)71590-5
(1967)
