150543-41-2Relevant academic research and scientific papers
Preparation method of 5-benzyl-5-N spiro[2. 4]heptane-1-carboxylic acid
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Paragraph 0032-0033, (2017/08/31)
The invention discloses a preparation method of 5-benzyl-5-N spiro[2. 4]heptane-1-carboxylic acid. The preparation method comprises that through a series of Swern oxidation reaction, Wittig reaction, sulfur ylide reaction and hydrolysis reaction, 5-benzyl-5-N spiro[2. 4]heptane-1-carboxylic acid is prepared from 1-benzyl-3-hydroxypyrrolidine. The preparation method utilizes a reaction of the double bond and the sulfur ylide to produce the ternary ring, utilizes cheap and easily available raw materials, has mild conditions, utilizes a simple operation way and greatly improves the possibility of industrialization.
DIAZA-SPIRO-[4.4]-NONANE DERIVATIVES AS NEUROKININ (NK1) ANTAGONISTS
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Page/Page column 37, (2008/06/13)
This invention concerns substituted diaza-spiro-[4.4]-nonane derivatives having neurokinin antagonistic activity, in particular NK1 antagonist ic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the
