311-46-6Relevant articles and documents
Alkyl phosphonate preparing method
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Paragraph 0068; 0069; 0070; 0071, (2017/10/07)
The invention provides an alkyl phosphonate preparing method. The method comprises: performing an Arbuzov reaction on compound A and compound B in a continuous reaction apparatus, and continuously discharging the product obtained from the reaction from the continuous reaction apparatus during the reaction procedure, to obtain alkyl phosphonate. The reaction temperature in the reaction procedure is T1; either of compound A and compound B having a lower boiling point has a boiling point at a standard atmosphere pressure to be T2; T1 is higher than T2 by 10-40 DEG C; and the reaction pressure in the reaction procedure is 0.5-2.0 MPa. The preparing method in the invention may use halohydrocarbon having large steric hindrance and lower polarizability of carbon-halogen bond as compound A, thereby effectively expanding a selection range of substrate, and correspondingly expanding the types of alkyl phosphonate prepared by using the Arbuzov reaction.
A facile synthesis of novel chiral phosphonoacetates bearing a stereogenic phosphorus atom
Sano, Shigeki,Kujime, Eiko,Takemoto, Yuka,Shiro, Motoo,Nagao, Yoshimitsu
, p. 131 - 134 (2007/10/03)
Novel chiral phosphonoacetates bearing a stereogenic phosphorus atom were successfully synthesized by enzyme-catalyzed kinetic resolution of racemic phosphonoacetates.
Intramolecular cyclopropanation reactions en route to novel P- heterocycles
Hanson, Paul R.,Sprott, Kevin T.,Wrobleski, Aaron D.
, p. 1455 - 1458 (2007/10/03)
The first examples of intramolecular cyclopropanation reactions on a phosphonate template catalyzed by Rh2(OAc)4 are described. These reactions proceed in excellent yield and give mixtures of the P-heterocycles cis-2a-d and trans-2a-d with moderate levels of diastereoselectivity. The diastereoselectivity of this transformation is dependent upon the size of the alkyl group R contained in the alkyl α-diazodiallylphosphonoacetate starting materials 1a-d.