1505448-11-2Relevant academic research and scientific papers
Intramolecular fischer indole synthesis in combination with alkyne hydroarylation: Synthesis of tetracyclic chromeno-indoles
Park, Jun,Kim, Sun-Young,Kim, Ji-Eun,Cho, Cheon-Gyu
supporting information, p. 178 - 181 (2014/01/23)
Aryl hydrazides bearing a carbonyl function connected through an alkyne tether underwent an intramolecular Fischer indolization and alkyne hydroarylation in a tandem fashion to afford novel tetracyclic chromeno-indoles. The accompanying isomerization of the 2H-chromene double bond can be avoided by stopping the tandem process at the indolophane stage and conducting the alkyne-hydroarylation reaction separately in the absence of a proton source.
